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Database: UniProt
Entry: A0A0D2S4A9_GOSRA
LinkDB: A0A0D2S4A9_GOSRA
Original site: A0A0D2S4A9_GOSRA 
ID   A0A0D2S4A9_GOSRA        Unreviewed;       321 AA.
AC   A0A0D2S4A9;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00019474};
DE            EC=5.3.99.3 {ECO:0000256|ARBA:ARBA00012203};
DE   AltName: Full=Microsomal prostaglandin E synthase 2 {ECO:0000256|ARBA:ARBA00031041};
GN   ORFNames=B456_009G193000 {ECO:0000313|EMBL:KJB58068.1};
OS   Gossypium raimondii (New World cotton).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB58068.1, ECO:0000313|Proteomes:UP000032304};
RN   [1] {ECO:0000313|EMBL:KJB58068.1, ECO:0000313|Proteomes:UP000032304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23257886; DOI=10.1038/nature11798;
RA   Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA   Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA   Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA   Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA   Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA   Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA   Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA   Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA   ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA   Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA   Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA   Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA   Wang X., Schmutz J.;
RT   "Repeated polyploidization of Gossypium genomes and the evolution of
RT   spinnable cotton fibres.";
RL   Nature 492:423-427(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-
CC         heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644,
CC         ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274;
CC         Evidence={ECO:0000256|ARBA:ARBA00023930};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645;
CC         Evidence={ECO:0000256|ARBA:ARBA00023930};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893,
CC         ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00023931};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894;
CC         Evidence={ECO:0000256|ARBA:ARBA00023931};
CC   -!- PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004702}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR   EMBL; CM001748; KJB58068.1; -; Genomic_DNA.
DR   RefSeq; XP_012447493.1; XM_012592039.1.
DR   AlphaFoldDB; A0A0D2S4A9; -.
DR   EnsemblPlants; KJB58068; KJB58068; B456_009G193000.
DR   GeneID; 105770719; -.
DR   Gramene; KJB58068; KJB58068; B456_009G193000.
DR   OrthoDB; 1226at2759; -.
DR   UniPathway; UPA00662; -.
DR   Proteomes; UP000032304; Chromosome 9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050220; F:prostaglandin-E synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03197; GST_C_mPGES2; 1.
DR   CDD; cd03040; GST_N_mPGES2; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR011767; GLR_AS.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR034334; PGES2.
DR   InterPro; IPR034335; PGES2_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12782:SF11; MICROSOMAL PROSTAGLANDIN E SYNTHASE 2; 1.
DR   PANTHER; PTHR12782; MICROSOMAL PROSTAGLANDIN E SYNTHASE-2; 1.
DR   Pfam; PF13410; GST_C_2; 1.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SFLD; SFLDG01182; Prostaglandin_E_synthase_like; 1.
DR   SFLD; SFLDG01203; Prostaglandin_E_synthase_like1; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   4: Predicted;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022585};
KW   Prostaglandin biosynthesis {ECO:0000256|ARBA:ARBA00022585};
KW   Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT   DOMAIN          93..169
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
SQ   SEQUENCE   321 AA;  36119 MW;  CB36E29CDAD785C0 CRC64;
     MRRVNGLATV GRALTCGGAV EKRLAQAALM STCSSSSLNS HIFSQKLADR LGLSRPSLVR
     RVAGTMLFSV AASSLAQDAL AKEKPRSEKF LPKEVVLYQY EACPFCNKVK AFLDYYNIPY
     KIVEVNPISK KEIKWSDYKK VPILKVDGEQ MVDSSDIIDK LFHRINPDSS IPDGEEKKWR
     EWVDNHLVHV LSPNIYRSTS EALESFDYIT THGNFSFTER LVAKYAGAAA MYFVSKKLKK
     KHNITDERAA LYEAAETWVD ALDGRHYLGG SKPNLADLAV FGVLRPIRYL TSGKDMVEHT
     RIGEWYGRME NAVGESARIK E
//
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