ID A0A0D2S5Y0_GOSRA Unreviewed; 3085 AA.
AC A0A0D2S5Y0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 13-SEP-2023, entry version 46.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=B456_006G189100 {ECO:0000313|EMBL:KJB37086.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB37086.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB37086.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CM001745; KJB37086.1; -; Genomic_DNA.
DR EnsemblPlants; KJB37086; KJB37086; B456_006G189100.
DR Gramene; KJB37086; KJB37086; B456_006G189100.
DR Proteomes; UP000032304; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1957..2622
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2728..3041
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3053..3085
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1908..1927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2484..2511
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2063..2082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3085 AA; 351276 MW; 7E623DD2240AF18C CRC64;
MVTSSDVQEI VSKLSSDKAK AREDGIKLLS MWLEGERSIG FCKVIGQHTA KLKPNEIPQS
ETWPFLIKLL TQCVSLEIST SKRRPPKLIF AKTLRTAIQR AEDTKFPGNV YPLLSVVKTL
FSHILDVINN VPSFQSEYGI ILRHLLLVKE YRFHMRKNIY SGLMVFYLEK VATTLTEKNN
TQYSQKEEIF RSILALHSLL ENPAGDFPDH LREDIVKGFV KIFSYIRDEG KVSRKLIECI
NTYLLKDGPN LSCQSLEIHN AVQQFVFRCW LMTHDKGLKD ALVLYARLQL NLVRGVTEGS
LLVEQLLDVI SKELDQSNSS IPGTSWRDGT KDDKFGTLSS SQQHLVELAA LVLYRACATT
SRATSNEKRA KRESTAARLK EELVKGKWLW NVTFCYLIRN YYTRISKDLF IYWFEGICAS
FERILNDANV EHAYDGLLWT LRSLQELSLM ELPSNAQVEI SLRSSLISKE FDCGWQLIWS
HLMHGLPTFS NVTPVVDAAL ALLGSIISND LSNTCVVPHD AWDLRLFKGM PSLCTLYFIA
CYFSRKGSQG DLRDILHLRK YLLRATLGSL SWNEPSLLNE RLVLLLPAAV YALCAGCEPF
TQCYKEIHLL QSFVDVIEVA DDWIKADEYD HEKQLENFEC SIEVLANIDL DSIIQVSSSH
FHQSLRLPRQ LRESLMQEME SCILGLLADL KFEKKPLSDI FFICALLCNF IYGLYFTRNR
EEVSSFLSKL GQILLELLNY AVNVIQENKN DSRSLGFLGF TSSFNQKSAI VVSFKTFVLG
PLFTQRRDDD ALDVVLYDAV KQSLQKLLKA FTELYDEYTE SITNLRSELL ASDSSGSDSS
IRISNHADSN KSRIMDMELD VDEDGKDMTI QTSSGKTPSG GSFSAVKWKL GMVSLISSFF
LVLHDKTWDV LSNLLGKELD FKVYEVILCN LCRRLPSLYS SKLTDLVNLI DNRIGVQVSQ
KLDCFNILAA IGYLLDTLLS LDVEKDKHGV VALEEREAKQ SLVCLGELVG KVAEFDLLNW
FGRVKLIDCI CNFVLLSPEV GQTMIGKLLS MLHDPDYRVR FILSRRIGVL FQTWDGHGEL
FHDICSNFGI ELIFYSKEKL VTAREVLAAG PQPRQKVETV IITLMQLALH SENIELEAVF
MMCAVSSIDP CQRELVNAAL DNLARKLKYM SRMKYLEELI GSILFCWVAC GVSIAALVEI
RQLFVLDAEP SYFLQYCFHW LLPALFIHED NSNLNWISKI AGQPLTVVVK DHFVPIFSVC
MTLHCSKSSG FEKGAMVLQN SILHFAEISE SERDKLIKKN MVSIVSHILS LASCASDPII
PFFSRDTIAR AIQTVVDGFL EMDDHCASIS VVDKINIFRP DRVFMFIVEM HYKIAAAIHH
RHRCHRLASI EVLITVLGHR AALSSTSNYL FNLIGQYIGC HALQDQCCCI ISSLLKTFKS
NPSKEIVGVL GEQLQFLVSK LVACCIPLEA EGQRSATVSS LFLSLLLELT VESDPSLYDY
IRELEPFPEV DIFERIRNFH HDLCRAYSPR DHLLKVLQPS TKITFMEKPI NTKSLPVHYE
VIFYKVIVFK MLKVLHSIFR LGSAEISDML LLLRCFMFLG PCSLQALHKK LLAGETFQGG
KTTKEFVDDT YWHGDGEIVH AVWTLVRMCA SDDSSRIRGL VSDLISRVGI GDPYSVVFHL
PGDSNHMHVH GPISHNGASE IMGSSVSEEL LIALLKVLKK YLMDDSVKIV DITSQTLRGI
LSTERGQKAI LSFDSYERSL IEVHSKGINS ELVEKLLMDL EKKFKAEDIF LEKSTTWVTH
GKTFEMWICP VVYSLVGCCS DVILRLCQDV VLLKPEVAEL LLPSVVVNLA GRKDIGVNIQ
SLISDQVQEH IFVKSNKLIK SIQVWLNALN ELRICYVLER SSGPLRKENS KHCRPSNFSS
RSHSSMKPRD SVATLSAVTM STSSWAKVYW LSIDYLIVAR SAITCGSYFT SMMYVEYWCE
EHFHGLTLGN PDFSNLEMLP QHIEILISAI TQINEPDSLY GIIQSHTLTS QIITFEHEGN
WNKALEYYDL QVRSEATAHM DGSSRTLSLT ETQSLSQPHL STSDDEAKWK PYKGLIRSLQ
QIGCRHMLDL YCQGLTSGKG QFQQDLEFTE LQYEAAWRAG NWDFSLLSAG PIPQSSEQHT
KTHHFNENLH CCLRALQEGD SDEFQRKLKH SKEELVWSVS CASEESTEFI YSTIIKFQIL
YHLGIAWEMR WPTSSFDRIE LQKHKQKMFS DPVIPTMDQL LWLNKDWSSM LTKSQLHMSL
LEPFIAFRRV LLQILNCHDC TMQHLLQSAS TLRKGSRFSQ AAAALHEFKF LCVRTGEQGS
SAYWLGRLEE AKLLRAQGQR EMAIGLGKYI LQTNRLDEEA SDVYRLVGKW LAETRSSNSR
TIFEKYLKPA VSLAEGDKTA DKKSAERKSQ THFRLAHYAD ALFRSYEERL NSNEWQAAMR
LRKHKTLELE ALMRRLKGST KGDKIDYSMK IQELQKQLAM DKEEAQKLQD DRDNFLNLAL
EGYKRCLVIG DKYDVRVVFR LVSLWFSLSY RQDVVNNLLK TIDEVQTYKF VPLVYQIASR
MGNIRDGIVP NNFQFALVSL LKKMAIDHPY HTIFQLLGLA NGDRIKDKQR SRNSFVVDLD
KKLAAENLLE ELSAYHGPVI RQMKQMVEIY IKLAELETKI EDTSRKVPLP REIRSVRQLE
LVPVVTASFP VDRSCRYCEG SFPYFRGLAD SVMVMNGVNA PKVVECLGSD GHKYKQLAKS
GNDDLRQDAV MEQFFGLVNT FLQNHRDTWK RRLVIRTYKV VPFTPSAGVI EWVDGTLPLG
EYLIGSNRNG GAHGRYGIGD WSFLKCRVHM SNEKDKRKAF QEVCENFRPV MHYFFLERFL
QPADWFEKRL AYTRSVAATS MVGYIVGLGD RHTMNLLIDQ ATAEVVHIDL GVAFEQGLML
KTPERVPFRL TRDIIDGMGV AGVEGVFRKC CEETLSVMRT NKEALMTIIE VFIHDPLYKW
ALSPLKALQR QKETDYDLDT SIEGSQDDYE GNKDAARALL RVKQKLDGYE EGEMRSVHGQ
VQQLIQDAID PERLCQMFPG WGAWM
//