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Database: UniProt
Entry: A0A0D2SUS3_GOSRA
LinkDB: A0A0D2SUS3_GOSRA
Original site: A0A0D2SUS3_GOSRA 
ID   A0A0D2SUS3_GOSRA        Unreviewed;       953 AA.
AC   A0A0D2SUS3;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   ORFNames=B456_008G046700 {ECO:0000313|EMBL:KJB47899.1};
OS   Gossypium raimondii (New World cotton).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae;
OC   Gossypium.
OX   NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB47899.1, ECO:0000313|Proteomes:UP000032304};
RN   [1] {ECO:0000313|EMBL:KJB47899.1, ECO:0000313|Proteomes:UP000032304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23257886; DOI=10.1038/nature11798;
RA   Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA   Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA   Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J.,
RA   Grover C., Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T.,
RA   Marler B.S., Page J.T., Roberts A.W., Romanel E., Sanders W.S.,
RA   Szadkowski E., Tan X., Tang H., Xu C., Wang J., Wang Z., Zhang D.,
RA   Zhang L., Ashrafi H., Bedon F., Bowers J.E., Brubaker C.L., Chee P.W.,
RA   Das S., Gingle A.R., Haigler C.H., Harker D., Hoffmann L.V., Hovav R.,
RA   Jones D.C., Lemke C., Mansoor S., ur Rahman M., Rainville L.N.,
RA   Rambani A., Reddy U.K., Rong J.K., Saranga Y., Scheffler B.E.,
RA   Scheffler J.A., Stelly D.M., Triplett B.A., Van Deynze A.,
RA   Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J., Zaki E.A.,
RA   Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA   Wang X., Schmutz J.;
RT   "Repeated polyploidization of Gossypium genomes and the evolution of
RT   spinnable cotton fibres.";
RL   Nature 492:423-427(2012).
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   EMBL; CM001747; KJB47899.1; -; Genomic_DNA.
DR   RefSeq; XP_012436533.1; XM_012581079.1.
DR   GeneID; 105763044; -.
DR   KEGG; gra:105763044; -.
DR   KO; K17108; -.
DR   Proteomes; UP000032304; Chromosome 8.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000032304};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT   DOMAIN       97    415       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      531    891       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   953 AA;  106851 MW;  17683651991BF348 CRC64;
     MSERKILENG FDEGDKDTSN HSINKVDTGK PPSLTWRRKL NGEGRVPSMF TLTFQEKLQM
     APIGIRLWQL IRESSAKGRR GIIIDPFAKR HITSSHGIPL GGVGAGSIGR SYKGEFQRWQ
     LFPRICEEKP VLANQFSVFV SRSSGEKYSS VLCPASSELL KEDAVSGIGS WDWNLRGNNS
     TYHALYPRAW TVYEGEPDPE LKIVCRQISP VIPDNYKESS FPVSAFTFTL YNTGNINADV
     TLLFTWANSV GGVSEFSGRH SNSKLIMKDG VHGVLLHHMT ADEQPPVTFA IAAQETDGIR
     ISECPCFLIS GNSQGITAKE MWQEIKEHGS FEHLKSTEAS VPSEQGSSIG AAIAASVTIP
     SDAVRTVNFS LAWDCPEVNF MGGKTYYRRY TKFYGSNGDA AANIAHDAIL EHNSWESQIE
     TWQRPVLEDK RLPEWYPFTL FNELYYLNSG GTIWTDGSSP VHSLVSIGGK KFSLDKSQLG
     LKSIIGVPHK NDTAIDILGR MTSILEQIHT PITSNSALGT NLLQEGEENI GQFLYLEGIE
     YHMWNTYDVH FYASFALIML FPKLQLSIQR DFAAAVMMHD PSKMKLLHDG QLVARKVLGA
     VPHDIGMDDP WFEVNAYCLY DTDRWKDLNP KFVLQVYRDV IATGDKKFAQ TVWPSVYVAM
     AYMDQFDKDG DGMIENDGFP DQTYDTWSVS GVSAYSGGLW VAALQAASAL AHEVGDKGSE
     DYFWYKFLKA KDVYQKLWNG SYFNYDNSGS RTSSSIQADQ LAGQWYARAC GLFPVVDEDK
     ARSVLEKVYN YNVLKVKGGK RGAVNGMLPD GRVDMSSMQA REIWSGVTYA VAATMIHEDL
     VDMAFHTASG IFESVWSEEG LGYSFQTPEA WNTDDQYRSL TYMRPLAIWA MQWALSRPKV
     PKQELKPEME ADSLRIHHAG FSKVARLLKL PEDQRSKSLL QIMFDYTCKR MLT
//
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