ID A0A0D2VCH4_GOSRA Unreviewed; 687 AA.
AC A0A0D2VCH4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=B456_013G117100 {ECO:0000313|EMBL:KJB80836.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB80836.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB80836.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; CM001752; KJB80836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2VCH4; -.
DR EnsemblPlants; KJB80836; KJB80836; B456_013G117100.
DR Gramene; KJB80836; KJB80836; B456_013G117100.
DR Proteomes; UP000032304; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Chloroplast {ECO:0000256|ARBA:ARBA00022528};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Plastid {ECO:0000256|ARBA:ARBA00022528};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT DOMAIN 553..687
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 437..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 76659 MW; FF5B9A0007E53023 CRC64;
MGAQKKGATA RVSEDPEELA RHPLQAILLA DSFTTKFRPI TLERPKVLLP LVNIPMINYT
LAWLESAGVE EVFVFCCAHS KQVIDYLESS EWSSQPNFSV TTIESHNSIS AGDALRLIYE
RNVIHGDFVL IRGDTVSNMS LTQALQEHKD RRKKDANAIM TMVVKQSKPS PITQQSRLGT
DELFMAINPV TKQLLYYEDK AEYSKGFISL DKTLIADNPS VILHNDKQDC YIDICSQEVL
SLFTDNFDYQ HLRRHFVKGL LVDDIMGYKI FTHEIHSSYA ARIDNFRSYD TISKDIIQRW
TYPFVPDVLC GSSAIKVERQ GTYRASDVTL SRSAQLGSFI FIGQGTKIGN DTKISHSVIG
ERCTIGSNVT IEGSYIWNNV TIEDGCQLRN AIVCDGVILK SGAVLQPGVI LSFKVVVGQQ
FVVPAYSKVS LLQQPTQQDS DEELEYADST SGTGELRSDK LNGDIAPDLS ETASELGTGG
VGYIWKVFEG AYDEEWRHSV APIPTDKLVK LMLDRDEDEE LLTQDGNVIS ASGELKTDSD
GNGSEDDDNE DSRDDYVSFE KEVEATFLRA VHENVKVDLA VLEVNALRLS YNMASVDCGG
AIFYSMMKLA VESPHNSASE LHRNAADIVT TWQKLLKSFL HDIDEEIEVI LKFEEMCLES
AKDFAALFPQ VFLMICLDLE DALMGSR
//
