ID A0A0D2X2D5_CAPO3 Unreviewed; 592 AA.
AC A0A0D2X2D5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN ORFNames=CAOG_003351 {ECO:0000313|EMBL:KJE92369.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE92369.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; KE346363; KJE92369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2X2D5; -.
DR STRING; 595528.A0A0D2X2D5; -.
DR EnsemblProtists; KJE92369; KJE92369; CAOG_003351.
DR eggNOG; KOG0540; Eukaryota.
DR InParanoid; A0A0D2X2D5; -.
DR PhylomeDB; A0A0D2X2D5; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008743}.
FT DOMAIN 78..334
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 337..584
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 592 AA; 63053 MW; 251C4EA200965CA6 CRC64;
MSLAAAALTI ARRGPLSGCA ASASLLRRSF TTATVAASTA TTVTAGVYPT YQGERQASVL
DGSVEANSDN FKENKTQMQA LVADLKAKVA HIVKGGGDEA RKRHTSKGKL LPRDRVAAVL
DPGSPFLEFS QFAGYKLYDD EIPAGGIITG IGRIAGTECI IVANDATVKG GTYYPITVKK
HLRAQEIAEQ NRLPCVYLVD SGGANLPNQA DVFPDRDHFG RIFYNQANMS GKGIPQIAVV
MGSCTAGGAY VPAMADESII VKGQGTIFLG GPPLVKAATG EVVSAEDLGG ADLHCKVSGV
TDHYALNDAH ALNIARRVVS NLNWRRTLPV TLTAPEEPLF PAEDLYGIVG ANLKKQFDVR
KVIARLVDGS RFDEFKAQYG TTLVTGFARL HGFPVGIVAN NGVLFSEAAL KGAHFIQLCS
QRGIPLIFLQ NITGFMVGKA AEAGGIAKNG AKMVTAVACA NVPKLTVVIG GSFGAGNYGM
CGRAYSPRFM WMWPNARVSV MGGEQAAGVL STITKEQRER KKLRPWTAEE EATFKQPTID
QYEKEGHPYF ASSRLWDDGV IDPADTRAVL ALGLSAALNQ PTPDPRFGVF RM
//
