ID A0A0D3AHZ4_BRAOL Unreviewed; 1116 AA.
AC A0A0D3AHZ4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=106327175 {ECO:0000313|EnsemblPlants:Bo2g007280.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo2g007280.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo2g007280.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo2g007280.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_013620700.1; XM_013765246.1.
DR AlphaFoldDB; A0A0D3AHZ4; -.
DR STRING; 109376.A0A0D3AHZ4; -.
DR EnsemblPlants; Bo2g007280.1; Bo2g007280.1; Bo2g007280.
DR GeneID; 106327175; -.
DR Gramene; Bo2g007280.1; Bo2g007280.1; Bo2g007280.
DR KEGG; boe:106327175; -.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_003532_0_1_1; -.
DR OMA; QFLPCET; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000032141; Chromosome C2.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF942; UBIQUITIN C-TERMINAL HYDROLASE 12; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 55..180
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 200..524
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 130914 MW; 0F7A47CDAF2E24AE CRC64;
MTMVTPPPVD QQEDEEMLVP HSDLVEDPAQ PMEVSETETA VSTVENQPAA EEPPTLKFTW
TIPHFSRINT RKQYSDVFVV GGYKWRILIF PKGNNVDHLS MYLDVADAAS LPYGWSRYAQ
FSLAVVNQVH TRYTIRKETQ HQFNARESDW GFTSFMPLSE LYDPSRGYLA NDTVYIEAEV
VVRKVLDYWS YDSKKETGFV GLKNQGATCY MNSLLQTLYH IPYFRKAVYH MPTTENDAPT
ASIPLALQSL FYKLQYNDTS VATKELTKSF GWDTYDSFMQ HDVQELNRVL CEKLEDKMKG
TVVEGTIQQL FEGHHMNYIE CINVDYKSTR KESFYDLQLD VKGCKDVYAS FDKYVEVERL
EGDNKYHAEG HGLQDAKKGV LFIDFPPVLQ LQLKRFEYDF MRDSMVKIND RYEFPLELDL
DREDGKYLSP DADRSVRNLY TLHSVLVHSG GVHGGHYYAF IRPTLSDQWY KFDDERVTKE
DLKRALEEQY GGEEELPQTN PGFNNPPFKF TKYSNAYMLV YIRESDKDKI ICNVDEKDIA
EHLRVRLKKE QEEKEDKRKY KAQAHLFTII KVARDQDLKE QIGKDIYFDL VDHDKVRSFR
IQKQTPFQQF KEEVAKEFGI PVQCQRFWIW AKRQNHTYRP NRPLTPQEEL QPVGQIREAS
NKANTAELKL FLEVELLDER PIPPPEKSKD DILLFFKLYD PEKPELRYVG RLMVKSSSKP
MDITGKLNEM AGFAPDEEIE LFEEIKFEPG VMCEHLDKKN SFRLCQIEDG DIICFQKPVV
NKEIECRYPA VPLFLEYVQN RQLVRFRALE KPKEDEFVLE LSKLHTYDDV VERVAEKLGL
DDPSKLRLTS HNCYSQQPKP QPIKYRGVDR LSDMLVHYNQ TSDILYYEVL DIPLPELQGL
KTLKVAFHHS TKEEVVIHNI RLPKQSTVGD VINELKTKVE LSHPDAELRI LEVFYHKIYK
IFPLTERIEN INDQYWTLRA EEIPEEEKNI GPNDRLILVY HFAKETGQNQ QVQNFGEPFF
LVIHEGETLE EIKNRIQKKL HVSDEDFAKW KFAFMSMGRP EYLQDSDVVY NRFQRRDVYG
AFEQYLGLEH TDTTPKRAYA ANQNRHAYEK PVKIYN
//
