ID A0A0D3B671_BRAOL Unreviewed; 773 AA.
AC A0A0D3B671;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase {ECO:0000256|PIRNR:PIRNR037274};
DE EC=2.7.1.68 {ECO:0000256|PIRNR:PIRNR037274};
GN Name=106333009 {ECO:0000313|EnsemblPlants:Bo3g035460.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo3g035460.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo3g035460.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo3g035460.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
CC Evidence={ECO:0000256|PIRNR:PIRNR037274};
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DR RefSeq; XP_013626948.1; XM_013771494.1.
DR AlphaFoldDB; A0A0D3B671; -.
DR STRING; 109376.A0A0D3B671; -.
DR EnsemblPlants; Bo3g035460.1; Bo3g035460.1; Bo3g035460.
DR GeneID; 106333009; -.
DR Gramene; Bo3g035460.1; Bo3g035460.1; Bo3g035460.
DR KEGG; boe:106333009; -.
DR eggNOG; KOG0229; Eukaryota.
DR HOGENOM; CLU_004312_6_4_1; -.
DR OMA; FYEVVMI; -.
DR OrthoDB; 340426at2759; -.
DR Proteomes; UP000032141; Chromosome C3.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17302; PIPKc_AtPIP5K_like; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 4.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR017163; PIno-4-P-5_kinase_pln.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR023610; PInositol-4/5-P-5/4-kinase.
DR PANTHER; PTHR23086:SF127; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE; 1.
DR PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR Pfam; PF02493; MORN; 8.
DR Pfam; PF01504; PIP5K; 1.
DR PIRSF; PIRSF037274; PIP5K_plant_prd; 1.
DR SMART; SM00698; MORN; 7.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR037274};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037274}.
FT DOMAIN 377..769
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 20..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 88463 MW; AC55A492A3A415B1 CRC64;
MSKEQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVSPHTD NDTSTDENDD ETSTNRSSLE
EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG DWYNGKTMGN GKFGWPSGAT
YEGEFKSGYM DGTGTYTGPS GDAYKGQWVM NLKHGHGVKS FANGDAYDGE WRRGLQEGHG
RYQWSDGCHY TGEWKNGTIY GKGSFVWTNG NRYDGCWDEG FPRGNGTYKW DDGSFYVGNW
SKDPEEMNGT YYPSGNEGNL EWDPKDLFDN LSEYTICSGE RVPMLPSQKK LSVWNSSKRI
EKPRRVSVDG RVSVGVDRAF EKMNMWGNET GEEGTDLRKE LDAELMRLEA EGIRSLKSSP
VPMKLPKAGR KQGETISKGH RNYDLMLNLQ LGIRHSVGRQ APVASLDLKP SAFDPKDKIW
RRFPREGTKY TPPHQSTEFK WKDYCPLVFR SLRKLFKVDP ADYMLSICGD DALRELSSPG
KSGSFFYLTN DDRYMIKTMK KSETKVLLRM LAAYYNHVRA FENSLVIRFF GLHCVRLNGP
TQKKVRFVIM GNLFCSKYSV HRIFDLKGSS LGRTTDKPES EIDSNTILKD RDLSFIFRLQ
KAWYQEFTRQ IDKDCEFLEQ ERIMDYSLLV GIHFRESSVA GDLIPSGAKT PIGESDEEAC
HRLSRAEVDQ LLSDPSRWAS IRLGTNMPAR AERTVRKSSD SELELVGEPT GEFYEVVLIF
GIIDILQDYD ISKKLEHAYK SIQYDPSSIS AVDPKQYSRR FRDFIFKAFT DDN
//
