ID A0A0D3C2F5_BRAOL Unreviewed; 700 AA.
AC A0A0D3C2F5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Nucleobase-ascorbate transporter 12 {ECO:0008006|Google:ProtNLM};
GN Name=106342929 {ECO:0000313|EnsemblPlants:Bo4g164850.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo4g164850.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo4g164850.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo4g164850.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013637447.1; XM_013781993.1.
DR AlphaFoldDB; A0A0D3C2F5; -.
DR STRING; 109376.A0A0D3C2F5; -.
DR EnsemblPlants; Bo4g164850.1; Bo4g164850.1; Bo4g164850.
DR GeneID; 106342929; -.
DR Gramene; Bo4g164850.1; Bo4g164850.1; Bo4g164850.
DR KEGG; boe:106342929; -.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_2_1; -.
DR OMA; NVSAYCR; -.
DR OrthoDB; 345287at2759; -.
DR Proteomes; UP000032141; Chromosome C4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF28; NUCLEOBASE-ASCORBATE TRANSPORTER 12; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 75504 MW; CEC68CD79A68FBC2 CRC64;
MSSSDPKPGP KPGPWPPAPE SSPMPPSTWA KRTGFRPKFS GETTASHSGQ LSLPASARAT
PSETLPDLEA GQPPLRPPPV SAGEPDKAKN DKPPPPPQPQ PPGAAAPVKR RRDSDGGRSN
GPDGEGANRS VRRQNRIEET VEVLPQSMAD DDIAARNLHM KYGLRDTPGL VPIGFYGLQH
YLSMLGSLIL VPLVIVPAMG GSHEDIANVV STVLFVCGIT TLLHTLFGSR LPLIQGPSFI
FLAPALAIIN SPAFQGLSAN NNFKHIMREL QGAIIIGSAF QAVLGYSGLM SLILRLINPV
VVAPTIAAVG LSFYSYGFPL VGKCIEIGVV QILLVVIFAL YLRKISILSH RIFLIYAVPL
SLAITWAAAF LLTEAGAYTY KGCDPNVPVS NVVSNHCRKY MTRMKYCRVD TSHALRSAPW
FRFPYPLQWG VPIFTWKTSL VMCVVSIIAS VDSVGSYHAS SLLVASMPPT PGVVSRAIGL
EGVTSLLAGL WGTGTGSTTL TENVHTIAVT KMGSRRVVEL GACVLVILSL VGKVGGFIAS
IPQVMVASLL CFMWAMFTAL GLSNLRYSEA GSSRNIIIVG LSLFFSLSVP AYFQQYGVSP
NSNLSVPSYY QPYIVASHGP FNSQYKGVNY VMNTLLSMNM VIAFIMAVVL DNTVPGSRQE
RGVYVWSDSE TVTREPALAK DYELPFRVGR FFRWVKWVGI
//
