ID A0A0D3CU78_BRAOL Unreviewed; 786 AA.
AC A0A0D3CU78;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase {ECO:0000256|PIRNR:PIRNR037274};
DE EC=2.7.1.68 {ECO:0000256|PIRNR:PIRNR037274};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo6g072470.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo6g072470.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo6g072470.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
CC Evidence={ECO:0000256|PIRNR:PIRNR037274};
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DR AlphaFoldDB; A0A0D3CU78; -.
DR STRING; 109376.A0A0D3CU78; -.
DR EnsemblPlants; Bo6g072470.1; Bo6g072470.1; Bo6g072470.
DR Gramene; Bo6g072470.1; Bo6g072470.1; Bo6g072470.
DR eggNOG; KOG0229; Eukaryota.
DR HOGENOM; CLU_004312_6_4_1; -.
DR OMA; EENLEWD; -.
DR Proteomes; UP000032141; Chromosome C6.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17302; PIPKc_AtPIP5K_like; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 2.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR017163; PIno-4-P-5_kinase_pln.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR023610; PInositol-4/5-P-5/4-kinase.
DR PANTHER; PTHR23086:SF134; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE; 1.
DR PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF01504; PIP5K; 1.
DR PIRSF; PIRSF037274; PIP5K_plant_prd; 1.
DR SMART; SM00698; MORN; 6.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR037274};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037274}.
FT DOMAIN 373..758
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 37..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 90008 MW; C0AB1239405D94D1 CRC64;
MSKEQGCVLK AWEVTVRKTQ QAKKRANNIF GTVSVASQTD DQATTTEEND DETSTNRSSI
GELYHAEREY FLMETTTQVN DGCMYIGEWY NEKTMGKGKF GWPSGATYEG EFKSGYMDGI
GTYTGPSGYT YRGQWVMNLK HGHGIKSYAN GDVYDGEWRR GLQEAQGKYR WRDESYYIGE
WKNGMICGKG TFIWTDGCRY DGFWDDGFPS GNGTFKWDDG SFYVGHWSQD PEEMNGAYYP
SGNEENLEWD PKDVFNNLSE YKTCSGERVP VLPSQKKLSV WNSSKRVEKP RRISVDGRVS
VGLDRAFEKM NMWGSESGEG AADIDSTTRR DLDAEIMRLE AEGFIQSLKP IPVPMRLPRA
GKKQGETISK GHRNYELMLN LQLGIRHAVG KQAAVVSLDL KHSAFDPKEK VWTRFPPEGT
KYTPPHQSSE FKWKDYCPLV FRSLRKLFKV DPADYMLSIC GNDALRELSS PGKSGSFFYL
TNDDRYMIKT MKKSETKVLL RMLAAYYNHV RAFENTLVIR FYGLHCVKLT GTIQKKVRFV
IMGNLFCSEY SVHRRFDLKG SSLGRTTDKP ESEINSNTIL KDLDLNFIFR LQKAWYQEFI
RQVDKDCEFL EQERIMDYSL LVGIHFREAS VAGELIPSGA RKPIGEFEDE SAPRLSRADV
DQLLSDPTRW ASIRLGGNMP ARAERTIRRS DCELVGEPTG EYYEVVMIFG IIDILQDYDI
SKKLEHAYKS IQYDPTSISA VDPRLYSRRF RDFIFKGLVD LLEFKPIPAG SDSPHSILRW
LCLQNP
//
