ID A0A0D3DFC6_BRAOL Unreviewed; 1354 AA.
AC A0A0D3DFC6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=106307032 {ECO:0000313|EnsemblPlants:Bo7g107740.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo7g107740.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo7g107740.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo7g107740.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_013599322.1; XM_013743868.1.
DR STRING; 109376.A0A0D3DFC6; -.
DR EnsemblPlants; Bo7g107740.1; Bo7g107740.1; Bo7g107740.
DR GeneID; 106307032; -.
DR Gramene; Bo7g107740.1; Bo7g107740.1; Bo7g107740.
DR KEGG; boe:106307032; -.
DR eggNOG; ENOG502QWPX; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR OMA; WEIEECG; -.
DR OrthoDB; 679287at2759; -.
DR Proteomes; UP000032141; Chromosome C7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF366; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141}.
FT DOMAIN 83..247
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1354 AA; 153035 MW; 69BF48513ED48C78 CRC64;
MDLSIFLNMV AAAIGFFFIL RKIRSHQENK EFDLSSLSTS SPPSSLTILS VPRSVYWSSL
SPSSPPSSLS ISSAPRPSSS QVWIHDVFLS FRGEDVRNNF LSHIQKEFKR KGITYFNDDG
IKRGESIAPE LIRGIRGSKI VIVLLSRNYG SSKWCLEELV EIMKCREELK QTVMAIFCKV
DPSDVKKLTG DFGKVFRKTC EGQAKEDIWR WKQALEKVAT IAGYHPSNWD DEASMVEEIA
TNVSNDLINF VISSDFEGFA GMEAHMQKME PFLLLGSNEV RIIGIWGPSG IGKSTIARVL
FSQHSHEFQL SVFMENIKRR CPRPCSDEYS AKLKLQEEFL SKIINQEDVK IHHLGVAPDR
LKDKRVLVVL DDVDHLMQLD AMAKDHSWFG PGSRIIVTTQ DKKILTAHGI NHIYKVEYPG
FSDAFEIFCM YAFGQKSPYD GFEKLAWEVK EFAGNLPLGL KVMGSYFKGM LKHEWEEELP
RLSARLDGEI ESSLKLRYDA LSVDTQDLFL HLACFFNNER IEKVEEYLAR NIVGVKGQLR
VLAEKSFISI VGGYIKIHDL LARLGREIVR KQSIHEPGQR QFLADVGDIC QVLQNDTLGS
RSVIGIDLKL LELETELKIS ERAFERMSNV QFLRLLHSDS DSDSGSDYGR PKQTCHHSID
LMTCLPPNLK LLHWDFFPMT CLPSNFISEF LVEIALRKSN YLEKLWEGNK TIRNLKWMYL
SDSKNLKELP DLSTATSLQE LNLHGCSNLA ELPFSIGNVI SLRRLNLSHC SSLVRIPSFI
WNLINLGRLD ISHCSSLVRL PSSSGNAIIK LKVLKLHGCT SLMELPSSME NATDLEELNL
TGCLRLAKLP SSIGNLKKLY LKDCSSLVEL PSSVRNSINL KDFTFNGCSN LVELPFYLGN
ATDLKKIDLS GCSSLQELPS SIGNMTNLMH LYLDECSSLL ELPSSIGNMT SLLYLYLNEC
SSLVELPSSI GNINNLMKLH LNGCSSLVEL PSSIGNMNNL GNLYLNGCSS LVELPSSIGN
INHLRKLSLN GCSSLVELPS SIGHMNHLRK LYLERCSKLR ALPININMKS LGKLFLTDCS
SLKCVPEIST NISVLKLTGT SIEELPRSIM SWPRLRELHL SDTRIQEIAP WVKERSSLRE
LVIKGCTKLV SLPQLPDSLK FLVADNCGSL ERLDCSFYKT KFHGLSFVNC FGLNQEAREI
IINTWTRDFA IFPGETVPTY FNYRATRSSL SMTWNGLDTQ YFPTSLRFKA CLLLVYKGDV
DADDWCWPDI SYCIKDKLNS VKSGYAAYAD LWHRSSPTSK EHLLVFKIEE KVGSPELAFE
FRSHDKNWEI EECGLRPMES WKQLLWNPWF VHGS
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