ID A0A0D3IWL3_EMIHU Unreviewed; 493 AA.
AC A0A0D3IWL3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EnsemblProtists:EOD15648, ECO:0000313|Proteomes:UP000013827};
RN [1] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [2] {ECO:0000313|EnsemblProtists:EOD15648}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR AlphaFoldDB; A0A0D3IWL3; -.
DR STRING; 2903.A0A0D3IWL3; -.
DR PaxDb; 2903-EOD15648; -.
DR EnsemblProtists; EOD15648; EOD15648; EMIHUDRAFT_356350.
DR eggNOG; KOG1339; Eukaryota.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827}.
FT DOMAIN 168..486
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 186
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 371
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 199..206
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 408..445
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 493 AA; 51941 MW; 0778514863E335A2 CRC64;
MAREEPLLPA SEGYVEYPAA RRQALPRWIT VAGAGMGVAT LLLLISAASQ HSAPTSSSSV
MPSAAAAGAA SGAVLSGVLD LPAQQQPQTH LLAAQSAREE PAAARKKGVH AVRLSKVERT
ARQHALELND ETSQGLFALG GATTNLIAAD GDAGTATVEL KDFQDAQYYG EISIGTPPQT
FSVVFDTGSA NLWVPSSRCK GFNLACFLHR RYASDKSDTF VRDGTPFAIK YGSGSMSGFI
SHDKISVGSL TLKNASFAEA VTEPGAAFVL SKFDGILGLA YPSLSVHCLT PVMQELIKQG
QLAAPLFSFW MSKDPKQTPG GMLFLGGVDD SYYTGDLHCL PITRKGYWQF DLDAVSVGGS
DVLTKGSAIA DTGTSLIVGP TEQLKKVIGK LGLADAQAGM GGQYSIPCDK KGELPTLSFT
LGGKTFSLES AEYVLEMELL GKKMCTLGLM PMDVPKPAGP LWILGDVFLS KYFSVYDFGN
DRVGFAEAVA TAP
//