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Database: UniProt
Entry: A0A0D3IWL3_EMIHU
LinkDB: A0A0D3IWL3_EMIHU
Original site: A0A0D3IWL3_EMIHU 
ID   A0A0D3IWL3_EMIHU        Unreviewed;       493 AA.
AC   A0A0D3IWL3;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS   Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC   Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC   Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903 {ECO:0000313|EnsemblProtists:EOD15648, ECO:0000313|Proteomes:UP000013827};
RN   [1] {ECO:0000313|Proteomes:UP000013827}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA   Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA   Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA   Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA   Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA   Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA   Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA   Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA   Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [2] {ECO:0000313|EnsemblProtists:EOD15648}
RP   IDENTIFICATION.
RG   EnsemblProtists;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; A0A0D3IWL3; -.
DR   STRING; 2903.A0A0D3IWL3; -.
DR   PaxDb; 2903-EOD15648; -.
DR   EnsemblProtists; EOD15648; EOD15648; EMIHUDRAFT_356350.
DR   eggNOG; KOG1339; Eukaryota.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013827}.
FT   DOMAIN          168..486
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        371
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        199..206
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        408..445
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   493 AA;  51941 MW;  0778514863E335A2 CRC64;
     MAREEPLLPA SEGYVEYPAA RRQALPRWIT VAGAGMGVAT LLLLISAASQ HSAPTSSSSV
     MPSAAAAGAA SGAVLSGVLD LPAQQQPQTH LLAAQSAREE PAAARKKGVH AVRLSKVERT
     ARQHALELND ETSQGLFALG GATTNLIAAD GDAGTATVEL KDFQDAQYYG EISIGTPPQT
     FSVVFDTGSA NLWVPSSRCK GFNLACFLHR RYASDKSDTF VRDGTPFAIK YGSGSMSGFI
     SHDKISVGSL TLKNASFAEA VTEPGAAFVL SKFDGILGLA YPSLSVHCLT PVMQELIKQG
     QLAAPLFSFW MSKDPKQTPG GMLFLGGVDD SYYTGDLHCL PITRKGYWQF DLDAVSVGGS
     DVLTKGSAIA DTGTSLIVGP TEQLKKVIGK LGLADAQAGM GGQYSIPCDK KGELPTLSFT
     LGGKTFSLES AEYVLEMELL GKKMCTLGLM PMDVPKPAGP LWILGDVFLS KYFSVYDFGN
     DRVGFAEAVA TAP
//
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