ID A0A0D5LXT7_9GAMM Unreviewed; 301 AA.
AC A0A0D5LXT7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AJY48622.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:AJY48622.1};
GN ORFNames=KO116_00110 {ECO:0000313|EMBL:AJY48622.1};
OS Halomonas sp. KO116.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1504981 {ECO:0000313|EMBL:AJY48622.1, ECO:0000313|Proteomes:UP000028645};
RN [1] {ECO:0000313|EMBL:AJY48622.1, ECO:0000313|Proteomes:UP000028645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KO116 {ECO:0000313|EMBL:AJY48622.1,
RC ECO:0000313|Proteomes:UP000028645};
RX PubMed=25953187;
RA O'Dell K.B., Woo H.L., Utturkar S., Klingeman D., Brown S.D., Hazen T.C.;
RT "Genome Sequence of Halomonas sp. Strain KO116, an Ionic Liquid-Tolerant
RT Marine Bacterium Isolated from a Lignin-Enriched Seawater Microcosm.";
RL Genome Announc. 3:0-0(2015).
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DR EMBL; CP011052; AJY48622.1; -; Genomic_DNA.
DR RefSeq; WP_035556183.1; NZ_CP011052.1.
DR AlphaFoldDB; A0A0D5LXT7; -.
DR STRING; 1504981.KO116_00110; -.
DR KEGG; hak:KO116_00110; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_1_6; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000028645; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AJY48622.1}.
FT DOMAIN 9..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 169..287
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 175
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 301 AA; 31188 MW; 408063ECFD84670A CRC64;
MSLIAEPLTI TVIGLGQMGG NMALTLKAAG FEVTGSDVFE QARSRLAAQG LTVVVPEELP
ASDVYLLSLP TSAHVREVIE QSPGLLNLAP KGSVIVDTST SDPAVTRELA EKVTAAGLLW
LDAPVSGGPK GAASGKLGML LGGDERTIER VLPMLEAMSS KRTHVGGPGS GHVVKLANNY
LCAAHLLTTA EAVAMAAKAG VDPAACLAGL NSGSGRSAVS EVNFPDWVLS ERFDSGFTSG
LMRKDLRLAR DAAEQLGIPL PLLQAVVDAW HANPEQPADS DDFNHITTPI LARGSQAEGN
Q
//
