ID   A0A0D5M4N1_9GAMM        Unreviewed;       472 AA.
AC   A0A0D5M4N1;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:AJY50748.1};
DE   Flags: Precursor;
GN   ORFNames=KO116_02273 {ECO:0000313|EMBL:AJY50748.1};
OS   Halomonas sp. KO116.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1504981 {ECO:0000313|EMBL:AJY50748.1, ECO:0000313|Proteomes:UP000028645};
RN   [1] {ECO:0000313|EMBL:AJY50748.1, ECO:0000313|Proteomes:UP000028645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KO116 {ECO:0000313|EMBL:AJY50748.1,
RC   ECO:0000313|Proteomes:UP000028645};
RX   PubMed=25953187;
RA   O'Dell K.B., Woo H.L., Utturkar S., Klingeman D., Brown S.D., Hazen T.C.;
RT   "Genome Sequence of Halomonas sp. Strain KO116, an Ionic Liquid-Tolerant
RT   Marine Bacterium Isolated from a Lignin-Enriched Seawater Microcosm.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP011052; AJY50748.1; -; Genomic_DNA.
DR   RefSeq; WP_035558280.1; NZ_CP011052.1.
DR   AlphaFoldDB; A0A0D5M4N1; -.
DR   STRING; 1504981.KO116_02273; -.
DR   KEGG; hak:KO116_02273; -.
DR   eggNOG; COG1502; Bacteria.
DR   HOGENOM; CLU_038053_1_0_6; -.
DR   OrthoDB; 9762009at2; -.
DR   Proteomes; UP000028645; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   CDD; cd09155; PLDc_PaCLS_like_1; 1.
DR   CDD; cd09161; PLDc_PaCLS_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        34..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          210..237
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          385..412
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   472 AA;  53436 MW;  46F9E7E4A4BECA6A CRC64;
     MTSWLLGTSI LLIHLLGIVS AIMALMSSRT SQGAVAWIIS LLTFPYVALP AYWFFGRPRF
     YGYVSARGQR DTVLRRVLVR YRANVEPFVA PSSNADIQAV EQLAMMPLTY GNHATLLIDG
     PVTFESLFDG IDRAEQYVLI QFFIVRGDAL GQRLKQHLQH AAQRGVRVYF LYDEVGSRQL
     NDGYLNDLIS DGVAVSAFRS SRGFKHRFQL NFRNHRKVTV IDGKEGWIGG FNIGVEYLGK
     DPRHGPWRDT HLKLEGPSVL GLQEAFWEDW HWATDEVISL NWMAETSSST DHHVVIVPSG
     PADRQDTASL LVQQVIHSAK QRLWVTSPYF VPDQGVQDAL RLAAMRGVDV RVMIPERPDH
     LLVFLSAFSF LPDMLRAGVK IYRYLPGFLH QKVMLVDNSA ATVGTVNLDN RSFRLNFEIT
     AFIPNQDFAA SVEVMLENDF SQCRRVSIDE INQRSMWMKV VSRAAYLMAP VQ
//