ID A0A0D7AGW8_9AGAR Unreviewed; 804 AA.
AC A0A0D7AGW8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cysteine proteinase {ECO:0000313|EMBL:KIY50677.1};
GN ORFNames=FISHEDRAFT_64821 {ECO:0000313|EMBL:KIY50677.1};
OS Fistulina hepatica ATCC 64428.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Fistulinaceae; Fistulina.
OX NCBI_TaxID=1128425 {ECO:0000313|EMBL:KIY50677.1, ECO:0000313|Proteomes:UP000054144};
RN [1] {ECO:0000313|EMBL:KIY50677.1, ECO:0000313|Proteomes:UP000054144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 64428 {ECO:0000313|EMBL:KIY50677.1,
RC ECO:0000313|Proteomes:UP000054144};
RX PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA Hibbett D.S.;
RT "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL Fungal Genet. Biol. 76:78-92(2015).
CC -!- SIMILARITY: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
CC {ECO:0000256|ARBA:ARBA00010193}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; KN881675; KIY50677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D7AGW8; -.
DR OrthoDB; 230045at2759; -.
DR Proteomes; UP000054144; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054144}.
FT DOMAIN 252..385
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
SQ SEQUENCE 804 AA; 89830 MW; 439C47418A53967A CRC64;
MVFTWTLLSC PRVAASGEAL YSKATKAELS RDYDLAFRLY VQAAEAFLHT SRSTSDPRQQ
ASLKADANKA LVRAEKIRNF TETKSASSSS ASGTHNLQAA PSLTPVGIDH FSSQEQFYVV
KKGSDINCRK FPLWSEALSS KSPPQFMDPE GQPELSSTQQ ELAPVWRRPP ATGERHILFP
WEVHQQVVTD CSFCASVAVC LQHNQRFDTQ RCDLRLFFNG DWRRVRLIST TNRLICLTCF
SHDRTEVPRQ VIWPSLLEKA YMKLMGGYDF PGSALTSWIP EQIEINRLFE RENTWERVYD
GFRDGTCLVT LGTGQRANIR WHNNRFLSAH NYAVIDVREK DGNRIVTVLD SWVQPDEDPQ
HSIAAASLPL AMPWDDVLAT FDGIYLNWDP QVWPNSLDHH GMWRNHSQGT VSTRHLHLQF
SRASNASADT VEVWVLLSRH AINTRETAEF IAISLQIEDP RMLGTLTQSS VRIQGDFTNS
LHRLAKIRIP SSMSTGLISM LCSYDGCHAE NGFSIRALAP SDITLEWVRE PVRPPFEAKV
DGRFTAKTAG GNPTYPTFMT NPQYYLRVLP TRERAAQGAR SSVLSFDVQT QRETPINIAV
VWSRGGERVT ELSQKEILAT SGPYSYGTAS LKRDSVPANF AVILSTFEPN QTGLYSLCVQ
SAHPVELQPI AQEGAGMYST TIEGEWTAST AGGSPSSKRY WSNPIYEVDV SVKQMIRLQL
ERPSSATAIN VTMFRAEDIE ANSASEHVAT SGGYDNALAG VCIPETAVMT GRYWIVPSTY
NPGVQTRFRM LAYTSAPVSE IKAL
//
