ID A0A0D7AN24_9AGAR Unreviewed; 956 AA.
AC A0A0D7AN24;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Dehydrogenase E1 and transketolase domain-containing protein 1 {ECO:0000313|EMBL:KIY53250.1};
GN ORFNames=FISHEDRAFT_63426 {ECO:0000313|EMBL:KIY53250.1};
OS Fistulina hepatica ATCC 64428.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Fistulinaceae; Fistulina.
OX NCBI_TaxID=1128425 {ECO:0000313|EMBL:KIY53250.1, ECO:0000313|Proteomes:UP000054144};
RN [1] {ECO:0000313|EMBL:KIY53250.1, ECO:0000313|Proteomes:UP000054144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 64428 {ECO:0000313|EMBL:KIY53250.1,
RC ECO:0000313|Proteomes:UP000054144};
RX PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA Hibbett D.S.;
RT "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL Fungal Genet. Biol. 76:78-92(2015).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; KN881627; KIY53250.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D7AN24; -.
DR OrthoDB; 3597773at2759; -.
DR Proteomes; UP000054144; Unassembled WGS sequence.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054144};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 599..804
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 956 AA; 107043 MW; EE03C7C565069B3F CRC64;
MPTGTVSPRG CRVPRFHSHA AFHTQTPDLE SSPHPNRCAV LIRRSYHDES FGFRKPREHT
FPDYTEAQLK NRHLNAPLLR YVDSVRMHGH RAARIDPLNL VPRLEVAALN PARYGLVDEQ
KPYDVNGIVW TAPVGANVEE HDRAQMWTLG EIISYMRTIY VDRIAYEYMH SPSKTERLFF
SKLLESSSVS PVTTDEKRRM LELIIRSETL DNFLQLKFPN LKRYGLEGGE SMIPALDTLF
SVASRAGIEH IVLCMPHRGR LNLLTELLEF PAAALFAKIT GGSELPEAYG GEGDVLSHLS
ASPELQYDDA VKPVRVSLLP NPSHLEAINP VALGKARAKQ YTLLKTSPPS CTLGDRVMCV
QLHGDASFTG QGIIMEGIGL SNLPHFTSGG SVHIVVNIGY TTPAAGARSS MYCSDIGKMI
GAPVLHVNGD YPEEVAKAME IAFEYRNYFR KDVIVDLLVY RRWHNELDLP DFTSPLMYDM
INSRRSVPAL YEEKLTTEGI AEEGTGKRIR DNYKEYLQSQ LVQAETYTPS PVVLQGQWSD
MVWPTDCDAF HNPATGVSTD VLKEAGHASI YVPEGFTVHP KLNRHIKHRL QGLDSEQQLD
FATAEAMSFG SLLREGYDIR ISGQDVGRGT FSQRHAMLVD QKTEQVIVPL NDRLAAPGKL
ELANSSLSEF AVLGFEYGVS WERPTLLPIW EAQFGDFFNG AQIIIDTFIS SAETKWLKQS
ALVLLLPHGL DGAGPEHSSS RIERMLQLTN DPFEYPHDNI TPNVNMHVIF PTTSAQYFHL
LRRQMKRNYR KPLIVASPKG LLRLPAASSS LADMALGTAF QPVIDDATVE PSNVARVVLV
AGKFYYELSK ERVTLNRQDV ALVRIEELCP FPFISLRAVL ARYPRAKDYL YVQEEPRNQG
AFPHVRERAN AVLDAMFPGQ HRKVRYVGRC ESAVPAPGIA KLYTTEQRAV LLEAFA
//
