ID A0A0D8XCN3_DICVI Unreviewed; 888 AA.
AC A0A0D8XCN3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Low-density lipoprotein receptor domain class A {ECO:0000313|EMBL:KJH41537.1};
GN ORFNames=DICVIV_12488 {ECO:0000313|EMBL:KJH41537.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH41537.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH41537.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH41537.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KN716805; KJH41537.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XCN3; -.
DR STRING; 29172.A0A0D8XCN3; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00135; LY; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51120; LDLRB; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KJH41537.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KJH41537.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 755..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 484..528
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 692..735
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 41..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 62..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 69..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 81..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 113..125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 120..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 132..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 725..734
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 888 AA; 99821 MW; 3BE70141257FE0C4 CRC64;
MQVVYLNLIS KALPLTCNNL TQFDCRTFAD PQGCIPLEWL CDGLKDCKNG LDESHCSYLH
SCPEGNFICR SGECVSGHYK CNGEVDCPGG EDENGCENHE TFIPAVSVPL SDCPEHMFHC
LHGPCIARAY ICDGEADCPL NEDERNCTNS DHSVSIKHEL TSCDTGMVLC ADRTVCFPKH
WVCDGEADCL DGSDEVSDCD MSVGNFLIES LTELCHPGEH RCSEAHMCIP LNRTCDGVRD
CPRGDDEGTL CNECQSRKTP CEYKCTNTPL GSRCICPHGS TLNADEFSCT QIDECLTIEA
KQCEQYCEDL HNSYQCTCAP GYQLGEDRHS CRLDRDHEGK LFVALGHEIR TMPLFESRSS
QEGYETVQSL GSHGVVRSID FVANRQLIYM TISGSDLQGE VAVSVGGLLR VVRENIVGVG
QVAVDWMNGN FFFTQRYPSQ TPGIRICSQD GFFCRRIIKG QTANIHDHKK RQYYRGIALH
PQRGSMVWIE SFNGRHKIML ASMDGANVRI LVENKLEYPT GISIDFIRND VYFGDIEREM
IERVNIDTQE RTVILTKGVH HPYDLKYFNG FLYWTDWASS SLKVAELSVH HEFPHLIHSF
ITLPYGLAIN HSMYQPTPSS NPCVLNDCQW ICVSILDVVG KLQPKCLCPD GYHPWTNDDC
IPFNDSVIAE VHRPPVEEGI ISDLSHIGVA WMKERCDDGD GCLNGGQCED VKNEHGRVTQ
IVCNCVSPYE GYRCERLNPY KELAEQLPAS SQPHWLTLFV IMTILLFFVA IFIFSYRYIN
QISNASKAVA MSLEQKVRLV LPHLQRVQQV IESIKTRLSS KLTNTSIRSC PRVFRTEINN
PLFSDEPPHS PEQSQNELSY SNPLFVENNS HGAPFSGINV TYSNKFVP
//