ID   A0A0D8XEP8_DICVI        Unreviewed;       793 AA.
AC   A0A0D8XEP8;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Histone deacetylase family protein {ECO:0000313|EMBL:KJH42197.1};
GN   ORFNames=DICVIV_11821 {ECO:0000313|EMBL:KJH42197.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH42197.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH42197.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH42197.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR   EMBL; KN716697; KJH42197.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8XEP8; -.
DR   STRING; 29172.A0A0D8XEP8; -.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766}.
FT   DOMAIN          401..714
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          65..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  86373 MW;  C4183E054CF63D60 CRC64;
     MDLMAHFERA QQALNIQHLQ QYCQALQQHT TAGTTTYPPT IERMDEGLCD VAATAFPVSS
     SMNSFLGFSQ SPTTSRDTQR IRSDRNATAN SSSQTISQHT KDRLKSMIAQ RSREGAQMNS
     VGVLPQQHTP INPQVNVSSP HFEPYRVPAS LHTVQTGSCQ TSGEYQLRKV NSEPNLKMRI
     RAKLLSKGSS PVQNQNSFNF THPQLKRSDS EKSSNGGGNM AMNTLLSNPT TFPHLIMPSP
     SLPNLSATNL THPQLPIGKD LRFIDMASLM AAAQLTPFLS LPSLFKTQIG LGCGLVDDEM
     IDGAKLATGV TTLGALSQQV PVGGYPSLLK QQLRELVLRR KSLVREEPED DDSPNTQDVL
     SPRQMPIPLG IGDLPSSKTT GLTYDSSMAR HECVCGESSS HVEHGGRVQS IWARLLERGL
     VQRCERIAAK KASLEHLRMV HSPTYVTFFA VSPTACLKME ASQLPLKSFV QLPCGGIGID
     SDTYFNDATT QTAARVAAGS LIELASQVAE NRLRNGFACI RPPGHHSERD QAMGFCFFNN
     VAITARYLQN KYPQQCARIA IIDWDVHHGN GTQLCFEEDP SVLYLSLHRH DNGNFFPGTG
     AVTEIGRGAG KGFSVNVPFS GGVMGDADYL AAWRVIVQPV LKQFQPTFIL VSAGFDACRG
     HPNALGGYTI SAEMFGFMTR QLMAYADGRV VLALEGGYDL ASISDAAEEC VKVLCGDDEK
     AGILKNDALE GIPCLSAQET IQKVIAIQKG YWPSLTAEQG LSISELHWQT VVVLKKEGIP
     SVSHDENTSD PRC
//