ID   A0A0D8XM90_DICVI        Unreviewed;       775 AA.
AC   A0A0D8XM90;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cullin family protein {ECO:0000313|EMBL:KJH44914.1};
GN   ORFNames=DICVIV_09032 {ECO:0000313|EMBL:KJH44914.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH44914.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH44914.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH44914.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN716439; KJH44914.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8XM90; -.
DR   STRING; 29172.A0A0D8XM90; -.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          415..654
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   775 AA;  88621 MW;  58868DCF7E0675C0 CRC64;
     MTAYALGPKS VDFDKVWGNL QPSVIEIMNL HPMTKKDWDD KFHDVYDICV AIPEPLSSRL
     YSSIKRCIEM HVTSLYEKIS TAQSDELLNQ YYTMWKIYYK GSNYVHRLFG YLNNQFVKSK
     RSVEGDAYAN YATFLQKPDV KEIGCLAMDI WKEHLIEPIL DKLINLLLAA IGQDRLGNVP
     PNKDVIAGVI SSFLQIEEFE YSPSEPIALG VKLNYREPPR EFYQEAFESR FLAATEEYYS
     GLAQKLLSDL TCSKYMEAVI EALEAEERRS ATYVTQTSVS KVIRLCQDVM INAHKDKLHA
     VCHELITNEE RKDLRNMYRL LKPISSGLLV MAKEFEDYVR KKGLDLISTI SGENVPQQFV
     DNVLKVHEKF HAMKTEVFMD DGDFAGALDK YFSPFLFTQA LQSVVNVKEG SGPPRASERL
     ARYTDNLLRK SAKGMSESEV DQQLSKAIVI FRYIEDKDVF QKYYSKMLAS RLIMGFSVAM
     DAEEAMINKL KQACGYEFTS KLSRMFTDIG LSNELADKFN KHLENTHTSV NVSMQPLVLQ
     AGSWPLSAPQ VGTSNGVTDI VSFILPPILQ PSITEFEKYY IGAHNGRKLT WLFNMSHGEL
     RLTYLDKPYL ISMSVYQMAI LLCFQDKDSI TLSDISILTG ISGDALLRNV RSIIDANVLT
     TTSKELSTSS ELILNRALTC KRLRFRLATP QIVKNTEKEA ESVTHDRKYY MECAIVRIMK
     TRKVLKHSAL INEVIEQTRT RFTPDVAFIK KSIEDLIEKL YIQRTDQNDE YQYLA
//