ID A0A0D8XMK5_DICVI Unreviewed; 960 AA.
AC A0A0D8XMK5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=SPFH/Band 7/PHB domain protein {ECO:0000313|EMBL:KJH45034.1};
GN ORFNames=DICVIV_08932 {ECO:0000313|EMBL:KJH45034.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH45034.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH45034.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH45034.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; KN716432; KJH45034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XMK5; -.
DR STRING; 29172.A0A0D8XMK5; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd03406; SPFH_like_u3; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR033294; Erlin1/2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR15351:SF3; ERLIN; 1.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 334..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 18..110
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 122..208
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 216..310
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT DOMAIN 647..813
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 960 AA; 106906 MW; 633EB57B91BCDDE2 CRC64;
MVGYSPEPIN GKELSSTEYR LPLSEAGLAS GIATRVIIQP LDVLKIRFQL QEEPIHGRNS
GKYKGVVQSI RLIHKEEGVR SFWKGHVPAQ GLSAIYGLVQ FSSFEFLSRE IGCRLPGSNQ
SLRSLADFFC GGLSGCVAMT AAMPLDVIRT RLVAQSGNTV YRGTTHAFIY IWKKEGVVGY
FRGWAPSVAQ IAPFTGLQFA LYNFFLGIWP RIVVHRESTG SLVCGALAGT VAKTVLYPLD
MVRHRLQMNG FERRGFGRTS DYRDGMLRTM RMVVKKESFY GLFKGLWPSQ IKAAANSGCA
FLFYELFCDI LRARKNDDLL FGLGSSIMFR VIKAGFASSF CHMFLSMIIT GCLQGASWVP
ATKLVQVWYD AHSYGKMFSI LSCGSAMAGL FSLSFSLAQC IALSRDDSLP VHINKNEAVL
QFMTFARSTV IWSISILYLF SVEVRTVCET WIPIYVVENG LSLKSFQIAY EIGGVFGNLC
SGMLLDKLSL YMNINSACRT FGVGSSILLL FVAFFSSISM HCITIMGTFL GIFVNASINI
WSIAASRIVF VVIVGSVLAG SPLAYFVDVT GYDLFFPLFL GHVAILVLTV SLSAEFRLKK
NYPSDIKKEN IGITIISSSG DIIQSDAMVP QGVFLVIFVV TSILMITSLH HIEEGHVGVY
YRGGALLTKV SAPGYHLMVP FVTSYKSVQV TLQTDEAKNV PCGTSGGVMI YFDRIEVVNI
LSANSVYDIV KNYTVDYDKP LIFNKVHHEV NQFCSSHSLQ EVYIDLFDQI DENLKLALQK
DLTVMAPGLF VQAVRVTKPK IPEAIRHNYE QMEAEKTRLL VAIQHQKVVE KEAETERKKA
VIGLCLELSC SKLKKKAQVA SIMQKQTISE KETQKRISQI EDESHLASEK AKADAEFYRV
QKEAEANRVL LTPEFLELRR IEAIAKNNKI FYGQNIPSVF FHSENRAEPR VRNAEEFAAQ
//
