ID A0A0D8XQN6_DICVI Unreviewed; 792 AA.
AC A0A0D8XQN6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=DICVIV_06944 {ECO:0000313|EMBL:KJH46968.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH46968.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH46968.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH46968.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KN716326; KJH46968.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XQN6; -.
DR STRING; 29172.A0A0D8XQN6; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 2.
DR PIRSF; PIRSF001293; ATP6V0A1; 2.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 283..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 375..394
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 706..730
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
SQ SEQUENCE 792 AA; 90967 MW; 71D99F886D08E786 CRC64;
MHSQLSFVAG VIRRERLPAF ERLLWRACRG NVFLRTSEID DVLNDTVTGE PVNKTVFIIF
FQGDQLKTKV KKICEGFRAT LYPCPDTPQE RREMSIGVMT RIEDLKTVLG QTQDHRHRVL
VAASKNVRMW LTKVRKIKSI YHTLNLFNID VTHKCLIAEC WCPISELERI RMALKRGTEE
SGSHVPSILN RMDTNEAPPT YHKTNKFTRG FQNIVDAYGI ATYREINPAP YTMISFPFLF
AVMFGDLGHG TIMLLASLFF ILKEKQLEAA RIKDEIFQTF FGGRYVIFLM GAFSIYTGLL
YNDVFSKSFN IFGSGWTNCY DLQEIDRLKF SEEKQLMLIP ENAYDSAGGP YPIGVDPVWN
LAESNKLTFL NSMKMKISVI LGIVQMTFGV LLSYQNYKYF KSELDIKFMF IPQIIFLASI
FIYLCLEIIV KWIRFTAGAQ DSIFGYKYPG SNCAPSLLIG LINMFMMKSL DSGFVEADGE
QKFQCHLNHW YPGQGFFQTL FVLIAVLCIP VMLFAKPYML WKADKQRRES GHRQLVSDER
VTLDNILVMS VSWKGRASRA FQAIVEQVLL VLAVVQVPVM LFVKPLMLRY RNRAAESHYH
SLRDESVRAN INGDDAEVVH ADSKNSSFSP RNSGGHETEP FELGEVMVYQ AIHTIEFVLG
SVSHTASYLR LWALSLAHAQ LSDVLWTMVF RHAFRLDGYY GALATYILFF IFGSLSVFIL
VLMEGLSAFL HALRLHWHKH LPLHRKCSLI MCAIGWNFNP NSMEDWVMSL LRSRLKKSLR
KKEKPRKICS LH
//
