ID   A0A0D9N2D9_ASPFA        Unreviewed;      1278 AA.
AC   A0A0D9N2D9;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=NRPS-like enzyme {ECO:0000313|EMBL:KJJ34340.1};
GN   ORFNames=AFLA70_333g001181 {ECO:0000313|EMBL:KJJ34340.1};
OS   Aspergillus flavus (strain ATCC MYA-384 / AF70).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=1392242 {ECO:0000313|EMBL:KJJ34340.1, ECO:0000313|Proteomes:UP000032444};
RN   [1] {ECO:0000313|Proteomes:UP000032444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-384 / AF70 {ECO:0000313|Proteomes:UP000032444};
RA   Yu J., Fedorova N., Yin Y., Losada L., Zafar N., Taujale R., Ehrlich K.C.,
RA   Bhatnagar D., Cleveland T.E., Bennett J.W., Nierman W.C.;
RT   "Draft genome sequence of Aspergillus flavus AF70.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NRP synthetase family.
CC       {ECO:0000256|ARBA:ARBA00029454}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJJ34340.1}.
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DR   EMBL; JZDT01000306; KJJ34340.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D9N2D9; -.
DR   OrthoDB; 3305653at2759; -.
DR   Proteomes; UP000032444; Unassembled WGS sequence.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          533..610
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1278 AA;  137536 MW;  FD66932C1E33800C CRC64;
     MSIIDTTKDL SALFTKQVQA TPDAIALEDE NTTYAYAELD QEVETLTRRL RGYGVGRDSL
     VGVLLPRSAD YVVACLAALR AGGAFLVLEL AYPPSLLADV IEDGRPTVVI TNRAEVGKIK
     ASVPVIIQDE PAPTANGHVS EPSPLPSDDD LDRLAFVSYS SGTTGKPKGI ANPHRAAVLS
     YNLRFGVSDL QQGDRVACNV FFVWEILRPL LRGATVVAVP DDASYDPAAL VDLLAAKKVT
     ETLMTPTLLA TVLARHPHVG DRLPDLRTLW FNGEVVTTDL ARRASKAFPQ TRLLNCYSAC
     ETHEIACGDI REMLQQIDSD ALYCPVGPPI DPENTYVLNE SLQKVDVGVS GELFLAGPQL
     ARGYLNLPET TAKAFITNPF DSDPSSRLYR TGDIARLLPS GLLEITGRVG AMIKLRGYSV
     VPAKVEYEIV TNLAVSRCAV VAYGEGLERQ LVAYIVRDKE KSAERPEVEI NDSGHSPAAR
     RTLAPHLAHY MIPALWVELD SLPTHEVTGK VDLKNLPPPQ SPQLVNGNGP KPAKDSIKLD
     EIASIWAAVL KTSRTLLKQS DDFFDLGGHS LSLADLSSRL SRHFGFRVPI TRLAENTTLT
     GHLETVRAIR DGHTAAVQAD LPAVLRADAT LDDEITPSNA TVCPIDKADT VLLTGVTGFL
     GAFLLHDLVE NTSARIICLV RFNEPANDDQ PGGIARIRRN LLDLGLWRDS IMERVEILPG
     NLSRTRFGLS PAAFDELASR VQVVVHAAAT VNLVYPYAAL RGPNVGGTRE VLRLACKGGA
     TVQYVSTNGV LPSSGESGWP EDALLDVDQV PDKLLDGYGQ TKWVAEQLVL EAARRGLPVK
     IHRAGTISGH SATGAANAWD LLTALIVESI HLGYAPDVDG WRAEMTPVDF VSKAIVHLAN
     QTHADQTVFH LGDPNPLSMN SVFAELRELG YPTQPLGWDE WVALWTQKRG PVKGGDGAFT
     VDILRSGMPT VEFLRGIVVL NNAATQPSLA DLDRPQVGRA LLETYTRHWF ARGWLTRPPS
     RQNALASSPK PKGPLHGKVA VVTGASSGIG AAVAVALARE GCHVALAARR ADALESVKGR
     MTAYGVKVIA RSTDVTNSGQ VEALLSAANE ELGPVDILVS CAGVMYFTMM ANVKTDEWDR
     TVDVNCKGLL HCLSATVPGM LSRSRGHIVA ISSDAGRKVF PGLGVYSASK FFVEATLQAL
     RLETAGTGLR VTSIQPGNTS TPLLNMSTDA EAVKKYGEPS GAQILDPEDI ANSIVYALRQ
     PEHVSVNEVL VEPRDEPI
//