ID A0A0D9QCN7_PLAFR Unreviewed; 618 AA.
AC A0A0D9QCN7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AK88_05625 {ECO:0000313|EMBL:KJP84744.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP84744.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP84744.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ030413; KJP84744.1; -; Genomic_DNA.
DR RefSeq; XP_012338650.1; XM_012483227.1.
DR AlphaFoldDB; A0A0D9QCN7; -.
DR EnsemblProtists; KJP84744; KJP84744; AK88_05625.
DR GeneID; 24270939; -.
DR VEuPathDB; PlasmoDB:AK88_05625; -.
DR OMA; RHINKCY; -.
DR OrthoDB; 5386942at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
FT DOMAIN 11..131
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 392..430
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
FT REGION 219..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 70153 MW; 3EF100D44335C53D CRC64;
MSTMNCATLY GYELASQIDQ LVMRKIANEK IQVGENKNWP QQKTLFIIYS KNISTYSYLH
IILKKSLFLS ADITFVLIRV HKGCNEKRLI NLIKKINTRG KNTWLIILSP LSRHINKCYI
STFITEEKDV DRSNCALMWK LLFRGSRSST CGGDAHNDGC MTLVPPIPLA HPPPYLYTQS
DEAFLLCLLY ILHLRMIKKS EYIWTNAIAN ATIRKEKTVE GDSQNVSDPT EGNYPSRDNT
LPSNLCSDVK HINNVSPEIH NYLRSSTKYN LPCCVHAVLL FLKYYQIHVK GKNVLILSSN
INIFLSLFAC FFRNEISTTV YDPLRGEVLC RYSEEENKCY LRTSNLGKLH IRNKTDFKNK
CTIFSNSYVA TIKGYTKITH QDLSTLSKNI DRRIVKKADV IIIAIGCPYI LKKKNIKQGA
IVLDFGINLV PPRGRHMDSR VTSLCDSSVR NKRVDMEKGP PKVEEGNFPC RRGFFQRAKY
KKGANYNTLQ NRKGLVKHIC LSCSRIGKTA TCENFFGEET TRVKREGTSP SHSYNDCPIC
PPSGGIKRAH NKFHKIIPLK SRNSKIKFAN GLAKCLHNYA IVGDVDANCK QKCALVSSVP
GGLGLITTSM LFYNLYFN
//
