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Database: UniProt
Entry: A0A0D9QE10_PLAFR
LinkDB: A0A0D9QE10_PLAFR
Original site: A0A0D9QE10_PLAFR 
ID   A0A0D9QE10_PLAFR        Unreviewed;       964 AA.
AC   A0A0D9QE10;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   07-JUN-2017, entry version 13.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=AK88_05163 {ECO:0000313|EMBL:KJP85204.1};
OS   Plasmodium fragile.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP85204.1, ECO:0000313|Proteomes:UP000054561};
RN   [1] {ECO:0000313|EMBL:KJP85204.1, ECO:0000313|Proteomes:UP000054561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S.,
RA   Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Larimer J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S.,
RA   Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium fragile nilgiri.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KQ001741; KJP85204.1; -; Genomic_DNA.
DR   RefSeq; XP_012338188.1; XM_012482765.1.
DR   EnsemblProtists; KJP85204; KJP85204; AK88_05163.
DR   GeneID; 24270477; -.
DR   Proteomes; UP000054561; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054561};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054561};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    466    491       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    512    529       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    599    620       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    693    716       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    900    920       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      309    336       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   964 AA;  110291 MW;  23EABC4A6CEE6532 CRC64;
     MGIFRSETMK HGTLVLPSDR AREYLDCLGK NVDIQFIDMN EKTMKRQYKK YIQRIDDMER
     ILRFLEENIK KLPNVKIKKS KIDSFLEHDN VYELDQVEES LNRLYVQFVR FCNNNKDLVD
     ERNNAVEEKH VILTAINQLN PGGTKNGNIG NRLAESSLPY DEVNDESVSL QTNMMKDGMN
     MMMFTNISGV IKTKDQESFS RTIFRALRGN TYTYFQSIDE SADGARGGGG DENGDEGGAG
     ASSCMNNAND DDDVVDGGNE MNNGKGMKNE PKSVFVVYCQ GSSQSNIYNK ILKICKAYDV
     KTYDWPKTYE QGRQRLKELK EIITDKEKAL KAYEEYFINE IFVLINVVEP NKNSLIEEWK
     LFCKKERYIY NSLNCFEGSD ITLRCDCWFS ANDEEKIRHM LITKSSNDLV SALLLSDKVL
     TPNISPPTYI KTNIFTKSYQ SMVDTYGIPR YGEINPAIST IITFPFLFGI MYGDVGHGVC
     IFLFALFLIM INGRVKNKSQ NEMVSMLLDG RYMILLMGFF AIYAGFLYND FFSMPLNLFT
     SMFEVDKQVD SVLYYKRKQV MNETTGQMED ADPYVFGFDA KWLGAENELT YINSFKMKFS
     IIIGFLHMTF GVLMKGLNAL HYRRKMDFFF EFLPQLLMML SIIGYLVFLI IYKWVTPIGY
     GGYHKQGIIN TIINMYLLKD LTPQNQFYAH QGLVQAFLIA VFVLCIPLMF VCKPAIRTYH
     IMKEKKKKGK GGAGGGEAPG SYYPHHEEKE MTHTFNHLMG GGGTSSSPSL HKRSPNMGFP
     HGGNTNNRED DYLSPRRRNK PTDDEMEAHL LSPSSPEDPH GMEAESFGAG SAGADHHEEN
     ISEIWIEQLI ETIEFILGLI SNTASYLRLW ALSLAHQQLS SVFFEQTILN SLKKDSFMSV
     LINLIVFSQL FSILTIAVIL CMDTLECFLH SLRLQWVEFQ NKFYKGDGIP FRPFNIKKVL
     SDND
//
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