ID A0A0D9QQL2_PLAFR Unreviewed; 3244 AA.
AC A0A0D9QQL2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Kringle domain-containing protein {ECO:0000259|PROSITE:PS50070};
GN ORFNames=AK88_00838 {ECO:0000313|EMBL:KJP89395.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP89395.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP89395.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001651; KJP89395.1; -; Genomic_DNA.
DR RefSeq; XP_012333905.1; XM_012478482.1.
DR EnsemblProtists; KJP89395; KJP89395; AK88_00838.
DR GeneID; 24266152; -.
DR VEuPathDB; PlasmoDB:AK88_00838; -.
DR OMA; FIFQPFD; -.
DR OrthoDB; 227622at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR11319; G PROTEIN-COUPLED RECEPTOR-RELATED; 1.
DR PANTHER; PTHR11319:SF35; OUTER MEMBRANE PROTEIN PMPC-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00051; Kringle; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM01411; Ephrin_rec_like; 9.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..3244
FT /note="Kringle domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002344210"
FT TRANSMEM 2287..2309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2321..2339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2388..2414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2474..2494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2537..2561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2588..2611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2617..2636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2656..2674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2680..2703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 284..360
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT REGION 83..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1944..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2789..2853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3041..3069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3210..3244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1944..1960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3043..3065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3244 AA; 374890 MW; EDC773E7B2274BDC CRC64;
MSINWVSLFL TMWCLFVPRL KNEKRENLNI LDVNFVDGEW KNEQVGERGK RRPIGASQVK
IGDDASMGLN WGRRKRGHAS EMNGDMHKEV NGQGDKTMKE RRPAESFAQS RLKYIYVNRD
LYSALQIMLN QYCHPQISRC IEGTKSCFCF NKEKLIRHVN FPRCVDNCGK IIRCFGFPGT
AAVKSIPGEV VNRLKMKSCV ISKKQRKLDN LCGENKVFRF QNNKQYCIPH DLLDMDKVLK
SCFSEFSTIS PCAGFLENTE KDIAKFKVNY KKSMNSILYD LCNEDLEGNG EMYKGCQDKS
ISGKKCLPWS SLNVKEILGI EYTHNYCRNP EKLITIYCFV NMNGFVFREF CERKEDIIMN
DITYINESLY NFNVTMKNVS DFRLALTTGD CANLYAAMDD PLMNIIQEAP DYTYHNVDGD
IAVTISFKNF HMRIYHNVVL SMCACYMDYY STADFKPCLS KRYVTKVGNM LSSDHIFNTS
VNVFHVNKEQ SLSLNIDNVI MQNREIYIMH GEYSYECKNL RFLENTPKNL YQQLLNVDIS
KSTQKIITGL DSSKNYSTLY AYADKIFDLK TMLKRNVHFT KVPKSAHVGK AVHVDVDGRR
ANVNREDPHK LSFHKIYNLR NGSNLMCIKN PSYSTVSFTY VGLITYNNYN TSNVKYFLKK
ETTVFEDRVF LNDVANFSLT DHLFSFSAIS CTLTDTNFLK EFSSKIVEET QINRLRKYSG
AFYYNHFKSS FSRSPQNDIP ERGKKRNRFY TFSLQKIKQI DVSLNYLCER KKRLDALSSV
SLVNFSDFIF SPYEDFAHYF HVRSLPNSTH NTYLTTDLFL VVRTHFNIHV GEKTGSFKMS
ILSLWSHEED NYVSLWFVTS EHLTPFFLIK YDFYAPAFSF LEMVSPSVAT TNTSNMVIPA
PTGLQTSSTT NSTPLASYQS EAGSSNMPHP IAYIYTFSTK QPAMRKYRTS DFYDLTLVNT
RYTLKLARTN SIHKFTYLGD TFFIFLLQNN VVSLWNSNFE EIEFSDSSLD NFIKSTPIKI
QCLGNNTVTC FVLYEFHQIL WFDLILGEHT QFRSFTEAHP SGAHQLQKET SERGQKMKKV
SPKQSFLQQK SENKSLGIQA QNIPSKEVKK AYIKHIYTYT EKDLEIAFEL AKDMTVIRKL
DEYIIYVSSS ESNKLHIYST DKSERKIEYY KYVRNEHMSS YRVSSIFAYS YEDTNFINSF
IRKENEIQHA VWSFMHERLS TTKVIYKQNT WHVYNKNIEI VPFIKGDKRQ IKYFTISDMD
PSLKGQNIII HKKTGVILIN LNRIETPHME LRVTMHGLFH VSTSRVRFNV VCMKGHYFDK
KKCRPCPKGS YNNLKEIKKN MKWYTSCIPC KANKTTSVPV PTNEQHCVCD VGYEYIMDPK
NPHQFICFPC KFGEYKDTIS NNLCKGNGCI ENSSSYILGA KTEAESSCRC NPGYFLTFDV
FGSSICEKCL PHHYCPGKLE NIQKCPKHNE TLLDERTDFT TINSCLCKKG YEPINMKKVQ
ENGSREKHYY NLFFNTYTYK PNQINPKHIC MECKIGYYKD TVSSDKCKKC PKKSMNKKYG
SATIDSCNSC YSGYYKDSHQ VCSTCLPNHF CVGSFAPYGL TQYTGDAVIC PNNSVTEEPN
EYNNSFKNCL CVEGYVKHLQ ESYNLNEHCK LAPLNFYKDT ISNDLGTPCP SNSITLVEGA
KSIHECICNK GFFYSKKRGM CIECPIGYYC PEKNNKNKFR GPIKCPQNSG NVKTGSYELA
NCQCNFGYTP NAQVNKVINS YTSVKRDSSR HSRRHTNRHR SEQPNRFPSF VNFGKVLTRS
NTFIHIIANK DATHEQIKTN KKNPSFLLCS RCPNSTYKST IANEACHECP PNSVTLTNIN
NSDLYFCLCK EGYYLEEQIC KPCSFTKLYC QGESIFEVPP GIYNQIIQDI RRNIGSFGPS
HGRRFVNWVI REYSVLWGDE AHKGGSGDVH RGKGKIQKEG DESSNQGTSA DASQGVAQDG
SKGAAAIQPR GGAVPGKGRR QRKRRRKVPI GSYFAKPVPV MLLSRLSTIA DASTSLVLKR
HDLAGSPNRQ MNQKKKQDNS MNLLLRSFFY RDNDNVVYAK YQHLVKCPDH TAIPLGVDSA
HDYDDCKCAK GYYLESKDMK RSVKICKPCK EGTFKNFVGD ETSCVSCPPK STSLEGSVYP
THCFCKEGFF YSKQNCLACL EGATCKGGLY KNAMSMIQLG LENIHITAQD HVKPESKRGY
YLDELMTKNI DVSEWKFIKC PIQNACLERN KCHHSMNNYL CVECAKGYTN TFMRSVCVQC
PNNTVNIIIL FSIYITFCFI IILISYLNVS SGFYRRSIHS IVIKIAVNYI SSMLLINILD
DKNLLLPEFV HQLYIHITRL INIGESRRII SIDCLLRHYF DLSYADSFFY SSLLFFFIPV
LLMGTLTFML FVILKIYTLL RKKAIANKLD LLSIAKRERI HFLANSLEKS YSKERFIMIL
RYIKLQHYTW MDRTFIFFED MIPVYVTFLF MIHAKTSMRM FQLFDCSYIM YTKNLGRYIL
SGVSSVQCDL KTDYLKFFIL GLSGTVIWSL GIPLLSFFVL YTNRHNLFQE NVRIKYGFLH
NGYLPNRWYW EIIVFARKIF FLFITTVVLF PSDETNTSKL LLITFVAIFS LCVHFIFQPF
DKRNFFTLNK LENTSLFIWT STIVVISILL SIKLNEFLNF VILFSLILLH VMFSVKLLIC
LFYECIDNLR RKKAFYHVPI LSTFAKALVD VVQRRKRQEP LIYYDKNARQ ISIILPDCVM
EKKKKVRLFA DSFRRIFNNV RGFWTKGMKQ RRGNRHRGGS RASDNDSFGT CGSTHMGSHY
GSRDGQEQLK QGAGNLPNDE SLGNIQGGPP KERVKRRPTW AAKNDEQHGS LNVQGKKGNK
NDHHFFTHNL PEKEKKMSFC FFPINNNESV CANINKEQRM FAIEIYKELL DIFMKNVTLT
YISEIFFEFI FKITINIGNL IDNLDHKDKI FVSMDQEQNF KNIIQWSLER MEKCSENKKL
EENKINNLKN CKYDCGLLNL DVDTLQGPLL FEEERMESCR SVGKTAPGQS SRDTSGNSSL
SGKDPEIQVS DEEKEKLFSF FSDDLLDRKI PLSEFYLILT ELKLKYCGNL TAYFYMFMLY
KKLEKLQDKK KLRRLNKKLR KCQRISDTSK KKSHEQMIQK DKIKEKTALL YKEHKDLTKT
LEQLKRHYVN ISRNDSDNFS SEEFGVPDMD GNISLSSGGS MEGVLLSKGF DQKQPESDRD
VRRG
//
