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Database: UniProt
Entry: A0A0D9QVL5_CHLSB
LinkDB: A0A0D9QVL5_CHLSB
Original site: A0A0D9QVL5_CHLSB 
ID   A0A0D9QVL5_CHLSB        Unreviewed;      4303 AA.
AC   A0A0D9QVL5;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   22-NOV-2017, entry version 22.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSCSAP00000000404};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSCSAP00000000404};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000404, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000000404, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000000404}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000000404}.
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DR   EMBL; AQIB01134585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01134593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000002088; ENSCSAP00000000404; ENSCSAG00000004047.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DIPARRN; -.
DR   Proteomes; UP000029965; Chromosome 6.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1356   1570       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1869   1925       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4303 AA;  484302 MW;  D18619F0367A7558 CRC64;
     MGDAEGEDDV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
     LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSRMYLSCL
     TTSRSMTDKL AFDVGLQEDA IGEACWWTTH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
     RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL ALTEDQGLVV
     VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
     PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF
     SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE
     GMLSLVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS
     TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
     VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG RAEGTTQYSK
     WYFEVMVDEV APFLTAQATH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WTGHVARLVT SPGQHLLAPE DVVSCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV
     SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG
     PSRCLSHTDF VPCPVDTIQI VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPVRDDNK
     RLHPCLVDFH SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEDNLK KTKLPKTYMM
     SNGYKPAPLD LSHVRLTPAQ MTLVDRLAEN GHNVWARDRV GQGWSYSAVQ DIPARRNPRL
     VPYRLLDEAT KRSNRDSLCQ AVRTLLGYGY NIEPPDQEPS QVENQSRWDR VRIFRAEKSY
     AVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR WHLGSEPFGR
     PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDGFLPV CSLGPGQVGH
     LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKS LPQFEPVPLE HPHYEVARVD
     GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFHQHF RCTAGATPLA PPGLQPPAED
     EARAAEPDPD YENLRRSAGG WGEAENGKEG TAKEGAPGST PQAGGEAQPA RAENEKDATT
     EKNKKRGFLF KAKKVAMMTQ PPATPTLPRL PHDVVPADNR DDPEIILNTT TYYYSVRVFA
     GQEPSCVWVG WVTPDYHQHD MSFDLSKVRV VTVTMGDEQG NIHSSLKCSN CYMVWGGDFV
     SPGQQGRISH TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV
     IQFELGKQKN IMPLSAAMFQ SERKNPAPQC PPRLEMQMLM PVSWSRMPNH FLQVETRRAG
     ERLGWAVQCR EPLTMMALHV PEENRCMDIL ELSERLDLQR FHSHTLRLYR AVCALGNNRV
     AHALCSHVDQ AQLLHALEDA HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTPE
     TRAITLFPPG RSTENGHPRH GLPGVGVSTS LRPPHHFSAP CFVAALPVAG AAEAPARLSP
     AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MGIFGDEDVK
     QILKMIEPEV FTEEEEEEEE EEEEEEEEDE EEKEEDEEET AQEKEDEEKE EEEAAEGEKE
     EGLEEGLLQM KLPESVKLQM CHLLEYFCDQ ELQHRVESLA AFAERYVDKL QANQRSRYGL
     LMKAFSMTAA ETARRTREFR SPPQEQINML LQFKDGTDEE DCPLPEEIRQ DLLDFHQDLL
     AHCGIQLDGE EEEPEEETTL GSRLMSLLEK VRLVKKKEEK PEEERPAEES KPRSLQELVS
     HMVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISPSSV EDTMSLLECL
     GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEIRFPKMV TSCCRFLCYF CRISRQNQRS MFDHLSYLLE NSGIGLGMQG STPLDVAAAS
     VIDNNELALA LQEQDLEKVV SYLAGCGLQS CPMLVAKGYP DIGWNPCGGE RYLDFLRFAV
     FVNGESVEEN ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGIRR
     DRRREHFGEE PPEENRVHLG HAIMSFYAAL IDLLGRCAPE MHLIQACKGE ALRIRAILRS
     LVPLEDLVGI ISLPLQMPTL GKDGALVQPK MSASFVPDHK ASMVLFLDRV YGIENQDFLL
     HVLDVGFLPD MRAAASLDTA TFSTTEMALA LNRYLCLAVL PLITKCAPLF AGTEHRAIMV
     DSMLHTVYRL SRGRSLTKAQ RDVIEDCLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM
     PLKLLTNHYE RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDPELYRMA
     MPCLCAIAGA LPPDYVDASY SSKAEKKATV DAEGNFDPRP VETLNVIIPE KLDSFINKFA
     EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE KDKEIYRWPI KESLKAMIAW
     EWTIEKAREG EEEKTEKKKT RKISQSAQTY DPREGYNPQP PDLSAVTLSR ELQAMAEQLA
     ENYHNTWGRK KKQELEAKGG GTHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR
     GLKDMELDSS SIEKRFAFGF LQQLLRWMDI SQEFIAHLEA VVSSGRVEKS PHEQEIKFFA
     KILLPLINQY FTNHCLYFLS TPAKVLGSGG HASNKEKEMI TSLFCKLAAL VRHRVSLFGT
     DAPAVVNCLH ILARSLDART VMKSGPEIVK AGLRSFFESA SEDIEKMVEN LRLGKVSQAR
     TQVKGVGQNL TYTTVALLPV LTTLFQHIAQ HQFGDDVILD DVQVSCYRTL CSIYSLGTTK
     NIYVEKLRPA LGECLARLAA AMPVAFLEPQ LNEYNACSVY TTKSPRERAI LGLPNSVEEM
     CPDIPVLERL MADIGGLAES GARYTEMPHV IEITLPMLCS YLPRWWERGP EAPPPALPAG
     APPPCTAVTS DHLNSLLGNI LRIIVNNLGI DEASWMKRLA VFAQPIVSRA RPELLQSHFI
     PTIGRLRKRA GKVVSEEEQL RLEAKAEAQE GELLVRDEFS VLCRDLYALY PLLIRYVDNN
     RAQWLTEPNP SAEELFRMVG EIFIYWSKSH NFKREEQNFV VQNEINNMSF LTADNKSKMA
     KAGDTQSGGS DQERTKKKRR GDRYSVQTSL IVATLKKMLP IGLNMCAPTD QDLITLAKTR
     YALKDTDEEV REFLNNNLHL QGKVEGSPSL RWQMALYRGV PGREEDADDP EKIVRRVQEV
     SAVLYHLDQT EHPYKSKKAV WHKLLSKQRR RAVVACFRMT PLYNLPTHRA CNMFLESYKA
     AWILTEDHSF EDRMIDDLSK AGEQEEEEEE VEEKKPDPLH QLVLHFSRTA LTEKSKLDED
     YLYMAYADIM AKSCHLEEGG ENGEGEEEVE VSFEEKEMEK QRLLYQQARL HTRGAAEMVL
     QMISACKGET GAMVSSTLKL GISILNGGNA EVQQKMLDYL KDKKEVGFFQ SIQALMQTCS
     VLDLNAFERQ NKAEGLGMVN EDGTVINRQN GEKVMADDEF TQDLFRFLQL LCEGHNNDFQ
     NYLRTQTGNT TTINIIICTV DYLLRLQESI SDFYWYYSGK DVIEEQGKRN FSKAMSVAKQ
     VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV GFLHVFAHMM MKLAQDSSQI ELLKELLDLQ
     KDMVVMLLSL LEGNVVNGTI ARQMVDMLVE SSSNVEMILK FFDMFLKLKD IVGSEAFQDY
     VTDPRGLISK KDFQKAMDSQ KQFSGPEIQF LLSCSEADEN EMINCEEFAN RFQEPARDIG
     FNVAVLLTNL SEHVPHDPRL HNFLELAESI LEYFRPYLGR IEIMGASRRI ERIYFEISET
     NRAQWEMPQV KESKRQFIFD VVNEGGEAEK MELFVSFCED TIFEMQIAAQ ISEPEGEPET
     DEDEGAAEAG VEGAEESAAG PEGTAATAAA GATARVAAAM GRA
//
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