ID A0A0D9QWS5_CHLSB Unreviewed; 761 AA.
AC A0A0D9QWS5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=DENN domain containing 5A {ECO:0000313|Ensembl:ENSCSAP00000000814.1};
GN Name=DENND5A {ECO:0000313|Ensembl:ENSCSAP00000000814.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000814.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000000814.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000000814.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AQIB01085286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QWS5; -.
DR STRING; 60711.ENSCSAP00000000814; -.
DR Ensembl; ENSCSAT00000002507.1; ENSCSAP00000000814.1; ENSCSAG00000004477.1.
DR eggNOG; KOG2080; Eukaryota.
DR GeneTree; ENSGT00940000153678; -.
DR OMA; XHIQNIG; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000004477; Expressed in Ammon's horn and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17690; RUN1_DENND5A; 1.
DR CDD; cd17692; RUN2_DENND5A; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047294; RUN1_DENND5A.
DR InterPro; IPR047295; RUN2_DENND5A.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00593; RUN; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 1..72
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 261..424
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 428..536
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 608..756
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 155..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 87703 MW; C11BDE32AE7B8A41 CRC64;
MFADYEVFVI QPSQDKESWF TNREQMQNFD KASFLSDQPE PYLPFLSRFL ETQMFASFID
NKIMCHDDDD KDPVLRVFDS RVDKIRLLNV RTPTLRTSMY QKCTTVDEAE KAIELRLAKI
DHTAIHPHLL DMKIGQGKYE PGFFPKLQSD VLSTGPASNK WTKRNAPAQW RRKDRQKQHT
EHLRLDNDQR EKYIQEARTM GSTIRQPKLS NLSPSVIAQT NWKFVEGLLK ECRNKTKRML
VEKMGREAVE LGHGEVNITG VEENTLIASL CDLLERIWSH GLQVKQGKSA LWSHLLHYQD
NRQRKLTSGS LSMSGILLDS ERRKSDASSL MPPLRISLIQ DMRHIQNIGE IKTDVGKARA
WVRLSMEKKL LSRHLKQLLS DHELTKKLYK RYAFLRCDDE KEQFLYHLLS FNAVDYFCFT
NVFTTILIPY HILIVPSKKL GGSMFTANPW ICISGELGET QILQIPRNVL EMTFECQNLG
KLTTVQIGHD NSGLYAKWLV EYVMVRNEIT GHTYKFPCGR WLGKGMDDGS LERILVGELL
TSQPEVDERP CRTPPLQQSP SVIRRLVTIS PNNKPKLNTG QIQESIGEAV NGIVKHFHKP
EKERGSLTLL LCGECGLVSA LEQAFQHGFK SPRLFKNVFI WDFLEKAQTY YETLEQNEVV
PEENWHTRAR NFCRFVTAIN NTPRNIGKDG KFQMLVCLGA RDHLLHHWIA LLADCPITAH
MYEDVALIKD HTLVNSLIRV LQTLQEFNIT LETSLVKGID I
//
