ID A0A0D9QWV7_CHLSB Unreviewed; 421 AA.
AC A0A0D9QWV7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Vasopressin V1a receptor {ECO:0000256|ARBA:ARBA00021173, ECO:0000256|RuleBase:RU046427};
GN Name=AVPR1A {ECO:0000313|Ensembl:ENSCSAP00000000846.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000846.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000000846.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000000846.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC {ECO:0000256|RuleBase:RU046427}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily.
CC {ECO:0000256|RuleBase:RU046427}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01023198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008002074.1; XM_008003883.1.
DR AlphaFoldDB; A0A0D9QWV7; -.
DR STRING; 60711.ENSCSAP00000000846; -.
DR Ensembl; ENSCSAT00000002539.1; ENSCSAP00000000846.1; ENSCSAG00000004509.1.
DR GeneID; 103238632; -.
DR KEGG; csab:103238632; -.
DR CTD; 552; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR OMA; FSMVEVN; -.
DR OrthoDB; 2879183at2759; -.
DR BioGRID-ORCS; 103238632; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 11.
DR Bgee; ENSCSAG00000004509; Expressed in adrenal cortex and 2 other cell types or tissues.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IEA:Ensembl.
DR CDD; cd15385; 7tmA_V1aR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR001224; Vprs_V1A_rcpt.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF08983; V1R_C; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00752; VASOPRSNV1AR.
DR SMART; SM01164; DUF1856; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU046427};
KW Glycoprotein {ECO:0000256|RuleBase:RU046427};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427};
KW Receptor {ECO:0000256|RuleBase:RU046427};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU046427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU046427};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU046427}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 222..247
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU046427"
FT DOMAIN 71..351
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 47235 MW; 7F7AE92BA26F1706 CRC64;
MDSMRFSAGP DAGPSGNSSS WWPLATSAGN TSREAEALGE GNGPPRDVRN EELAKLEIAV
LAVTFTVAVL GNSSVLLALH RTPRKTSRMH LFIRHLSLAD LAVAFFQVLP QMCWDITYRF
RGPDWLCRVV KHLQVFGMFA SAYMLVVMTA DRYIAVCHPL KTLQQPARRS RLMIAAAWVL
SFVLSTPQYF VFSMIEVNNV TKARDCWATF IQPWGSRAYV TWMTGGIFVA PVAILGTCYG
FICYNIWRNI RGKTASRQSK GAEQAGAAFQ RGFLLAPCVS SVKSISRAKI RTVKMTFVIV
TAYIVCWAPF FIIQMWSVWD PKSVWTESEN PTITITALLG SLNSCCNPWI YMFFSGHLLQ
DCVQSFPCCQ NIKEKFNKED TDSMSRRQTF YSNNRSPTNS TGMWKDSPKS SKSIKFLPVS
T
//
