ID A0A0D9QWW5_CHLSB Unreviewed; 261 AA.
AC A0A0D9QWW5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=EEF1A lysine methyltransferase 2 {ECO:0000256|HAMAP-Rule:MF_03188};
DE EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_03188};
DE AltName: Full=Methyltransferase-like protein 10 {ECO:0000256|HAMAP-Rule:MF_03188};
DE AltName: Full=Protein-lysine N-methyltransferase METTL10 {ECO:0000256|HAMAP-Rule:MF_03188};
GN Name=EEF1AKMT2 {ECO:0000256|HAMAP-Rule:MF_03188,
GN ECO:0000313|Ensembl:ENSCSAP00000000854.1};
GN Synonyms=METTL10 {ECO:0000256|HAMAP-Rule:MF_03188};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000854.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000000854.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000000854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Protein-lysine methyltransferase that selectively catalyzes
CC the trimethylation of EEF1A at 'Lys-318'. {ECO:0000256|HAMAP-
CC Rule:MF_03188}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03188}.
CC Nucleus {ECO:0000256|HAMAP-Rule:MF_03188}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. EFM4 family. {ECO:0000256|HAMAP-Rule:MF_03188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01042263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01042264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01042265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01042266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01042267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QWW5; -.
DR STRING; 60711.ENSCSAP00000000854; -.
DR Ensembl; ENSCSAT00000002549.1; ENSCSAP00000000854.1; ENSCSAG00000004519.1.
DR eggNOG; KOG1271; Eukaryota.
DR GeneTree; ENSGT00390000013399; -.
DR OMA; YWEDAYQ; -.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000004519; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_03188; Methyltr_EFM4; 1.
DR InterPro; IPR026635; Efm4/METTL10.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12843:SF5; EEF1A LYSINE METHYLTRANSFERASE 2; 1.
DR PANTHER; PTHR12843; PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03188};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_03188}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03188};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_03188};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_03188}.
FT DOMAIN 81..211
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29020 MW; 1A4B26709F0F0048 CRC64;
MSWDADGGSG AEVAALSDKG SPGEDGFVPS ALGTREHWDA VYERELQTFR EFGDTGEIWF
GEESMNRLIR WMQKHKIPLD ASVLDIGTGN GVFLVELAKF GFSDITGIDY SPSAIQLSGS
VIEKEGLSNI KLKVEDFLNL STQLSGFHIC IDKGTFDAIS LNPDNAIEKR KQYVKSLSRV
LKVKGFFLIT SCNWTKEELL NEFSEGFELF EELPTPKFSF GGRSGNSVAA LVFQKMELTT
LGHFPERPHP KGERPMRSCF C
//
