ID A0A0D9R1V6_CHLSB Unreviewed; 386 AA.
AC A0A0D9R1V6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 08-NOV-2023, entry version 38.
DE RecName: Full=pepsin A {ECO:0000256|ARBA:ARBA00011924};
DE EC=3.4.23.1 {ECO:0000256|ARBA:ARBA00011924};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002595.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002595.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Shows particularly broad specificity; although bonds
CC involving phenylalanine and leucine are preferred, many others are also
CC cleaved to some extent. {ECO:0000256|ARBA:ARBA00002318}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AQIB01079283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01079291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R1V6; -.
DR STRING; 60711.ENSCSAP00000002595; -.
DR Ensembl; ENSCSAT00000004340.1; ENSCSAP00000002595.1; ENSCSAG00000006333.1.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000155036; -.
DR OMA; ENYMDME; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000006333; Expressed in blood.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05478; pepsin_A; 1.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR034162; Pepsin_A.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF22; PEPSIN A-3-RELATED; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Digestion {ECO:0000256|ARBA:ARBA00022757};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..386
FT /note="pepsin A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013108033"
FT DOMAIN 74..383
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 92
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 105..110
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 266..270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 309..342
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 386 AA; 41576 MW; 1813158F5A985427 CRC64;
MKWLLLLGLV ALSECIIHKV PLVRKKSLRR NLSEHGLLKD FLKKHNRNPA RKYFPQAEAP
THEQPLENYL DMEYFGTIGI GTPAQDFTVI FDTGSSNLWV PSVYCSSLAC TNHNRFNPQD
SSTYQSTSGT LSITYGTGSM TGILGYDTVK VGGISDTNQI FGLSETEPGS FLYYAPFDGI
LGLAYPSISS SGATPVFDNI WNQGLVSQDL FSVYLSADDQ SGSVVIFGGI DSSYYTGSLN
WVPVSVEGYW HISVDSITMN GEAIACAEGC QAIVDTGTSL LTGPTSPIAN IQSDIGASEN
SDGEMVVSCS AVSSLPDIVF TINGVQYPLP PSAYILQSQG SCTSGFEGMD VPTESGELWI
LGDVFIRQYF TVFDRANNQV GLAPVA
//