ID A0A0D9R4U1_CHLSB Unreviewed; 1070 AA.
AC A0A0D9R4U1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSCSAP00000003630.1};
GN Name=MCF2 {ECO:0000313|Ensembl:ENSCSAP00000003630.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000003630.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000003630.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000003630.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01130589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01130590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01130591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01130592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01130593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R4U1; -.
DR STRING; 60711.ENSCSAP00000003630; -.
DR Ensembl; ENSCSAT00000005408.1; ENSCSAP00000003630.1; ENSCSAG00000007411.1.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000156974; -.
DR OMA; HNRRWPG; -.
DR Proteomes; UP000029965; Chromosome X.
DR Bgee; ENSCSAG00000007411; Expressed in adrenal cortex and 5 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 140..233
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 640..820
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 832..954
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 389..419
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1070 AA; 123791 MW; AF355F0DDB709F9A CRC64;
IPQAAASAPW TPVSCGRIPG LPQSPDGCTF MPIAQAIPLQ VDMAMALQRV RIAEKYGKNY
LCLLQAVFVA ETDLLLRIKD ISHFLMQDIA FLSGGRGKDN AWIITFPENC NFRCIPEEVI
AKVLTYLTSI ARRNGPDSQF TIILDRRLDT WSSLKISLQK ISASFPGNLH LVLVLRPTSF
LQRTFTDIGF RFSQEDFMLK LPVVMLSSVS DLLTYIDDKQ LTPELGGTLQ YCHSEWIIFR
NAIENFALTV KEMAQMLQSF GTELAETELP DDIPSIEEIL AIRAERYHLL KNDITAVTKE
GKILLTNLEV PDTEGAVSSR LECHQQISGD WQTINKLLTQ VRDMETAFDG FWEKHQLKME
QYLQLWKFEQ DFQQLVTEVE FLLNQQAELA DVTGTIAQVK QKIKKLENLD ENSQELLSKA
QFVILHGHKL AANHHYALDL ICQRCNELRY LSDILVNEIK AKRIQLSRTF KMHKLLQQAR
QCCDEGECLL ANQEIDKFQS KEDAQKALQD IENFLEMALP FINYEPETLQ YEFDVILSPE
LKVQMKTIQL KLENIRSIFE NQQAGFRNLV HKHVRPIQFV VPTPENLITS RTPFFSSKQG
KKTWRQNQSN LKIEVVHDCQ EKRSSGQSSS LDNGNSLDVL KNHVLNELIQ TERVYVRELY
TVLLGYRAEM DNPEMFDLMP PLLRNKKDVL FGNMAEIYEF HNDIFLSSLE NCAHAPESVG
PCFLERKDDF QMYAKYCQNK PRSETIWRKY SECAFFQECQ RKLKHRLRLD SYLLKPVQRI
TKYQLLLKEL LKYSKDCEGS ALLKEALEAM LDLLKSVNDS MHQIAINGYI GNLNELGKMI
MQGGFSVWIG HKKGATKMKD LARFKPMQRH LFLYEKAIVF CKRRVESGEG SDRYPSYSFK
HCWKMDEVGF TEYVKGDNRK FEIWYGEKEE VYIVQAPNVD VKMTWLKEIR NILLKQQELL
TVKKRKQQDQ LTEQDKIQIS LQPNDEKQQG AFISTEETES EHTSTVVEVC EAIASVQAEA
NTVWTEASQS AEISEEPEEW SSNYFYPTYD ENEEENRPLM RPMSEMALLY
//
