ID A0A0D9R540_CHLSB Unreviewed; 862 AA.
AC A0A0D9R540;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSCSAP00000003729.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000003729.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000003729.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000003729.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; AQIB01128339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01128340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01128341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R540; -.
DR STRING; 60711.ENSCSAP00000003729; -.
DR Ensembl; ENSCSAT00000005510.1; ENSCSAP00000003729.1; ENSCSAG00000007466.1.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000158027; -.
DR OMA; TRWHTWR; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000029965; Chromosome 11.
DR Bgee; ENSCSAG00000007466; Expressed in Ammon's horn and 6 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 3.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 272..344
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 463..496
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 528..561
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 562..595
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 596..629
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 663..696
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 731..764
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 769..802
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 803..836
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 166..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 97505 MW; 888C4E92CC93FBE8 CRC64;
MAENTSHKSY RPLCVLTFKL NIFLTGMNPF YFHAVNVILH CLVTLVLMYT CDKTVFKNRG
LAFVTALLFA VHPIHTEAVA GIVGRADVLA CLLFLLAFLS YNRSLDQGCV GESFPSTVSP
FFLLFSLFLG TCAMLVKETG ITVFGVCLVY DLFSLSNKED KSSNGALCPC SPQQPGSPQP
SSLPGHPHRE NGKQQRFPHK GAWGGCHSPL PPEPKSSGFP VSPRAVWSML RYLRASSNRN
FLLTMRPFLK RAILVLSYVL VILYFRLWIM GGSMPLFSEQ DNPASFSPYI LTRFLTYSYL
LAFNVWLLLA PVTLCYDWQV GSIPLVETIW DMRNLATILL AVVMALLSLH CLAAFKRLEH
KEVLVGLLFL VFPFIPASNL FFRVGFVVAE RVLYMPSMGY CILFVHGLSK LCTWLNRCGA
TTLIVSTVLL LLLFSWKTVK QNEIWLSRES LFRSGVQTLP HNAKVHYNYA NFLKDQGRNK
EAIYHYRTAL KLYPRHASAL NNLGTLTRDT AEAKMYYQKA LQLHPQHNRA LFNLGNLLKS
QEKKEEAITL LKDSIKYGPE FADAYSSLAS LLAEQERFKE AEEIYQAGIK NCPDSSDLHN
NYGVFLVDTG LPEKAVAHYQ QAIKLSPSHH VAMVNLGRLY RSLGENSMAE EWYKRALQVA
HKAEILSPLG ALYYNTGRYE EALQIYQEAA ALQPSQRELR LALAQVLAVM GQTKEAEKMT
NHIVSEETGC LECYRLLSAI YSKQENHDKA LDVIDKALQL KPKDPKVISE LFFTKGNQLR
EQNLLDKAFE SYRAAVQLNP DQAQAWMNMG GIQHIKGKYV SARAYYERAL QLVPDSKLLK
ENLAKLDRLE KRLQEVREKD QT
//
