ID A0A0D9R6U2_CHLSB Unreviewed; 1742 AA.
AC A0A0D9R6U2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Meiosis regulator and mRNA stability factor 1 {ECO:0000256|ARBA:ARBA00022152};
DE AltName: Full=Limkain-b1 {ECO:0000256|ARBA:ARBA00030116};
GN Name=MARF1 {ECO:0000313|Ensembl:ENSCSAP00000004331.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004331.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004331.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004331.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR EMBL; AQIB01118339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007984629.1; XM_007986438.1.
DR STRING; 60711.ENSCSAP00000004331; -.
DR Ensembl; ENSCSAT00000006119.1; ENSCSAP00000004331.1; ENSCSAG00000008067.1.
DR GeneID; 103228794; -.
DR CTD; 9665; -.
DR eggNOG; ENOG502QUYZ; Eukaryota.
DR GeneTree; ENSGT00390000002393; -.
DR OMA; SCCGKLH; -.
DR OrthoDB; 5311892at2759; -.
DR BioGRID-ORCS; 103228794; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 5.
DR Bgee; ENSCSAG00000008067; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR CDD; cd09977; LOTUS_1_Limkain_b1; 1.
DR CDD; cd09978; LOTUS_2_Limkain_b1; 1.
DR CDD; cd09979; LOTUS_3_Limkain_b1; 1.
DR CDD; cd09980; LOTUS_4_Limkain_b1; 1.
DR CDD; cd09981; LOTUS_5_Limkain_b1; 1.
DR CDD; cd09982; LOTUS_6_Limkain_b1; 1.
DR CDD; cd09983; LOTUS_7_Limkain_b1; 1.
DR CDD; cd09984; LOTUS_8_Limkain_b1; 1.
DR CDD; cd10910; PIN_limkain_b1_N_like; 1.
DR CDD; cd12255; RRM1_LKAP; 1.
DR CDD; cd12256; RRM2_LKAP; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.610; LOTUS domain-like; 6.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR024768; Marf1.
DR InterPro; IPR045602; MARF1_LOTUS.
DR InterPro; IPR034189; MARF1_RRM1.
DR InterPro; IPR034191; MARF1_RRM2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021139; NYN.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14379; LIMKAIN B LKAP; 1.
DR PANTHER; PTHR14379:SF82; MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1; 1.
DR Pfam; PF19687; MARF1_LOTUS; 1.
DR Pfam; PF11608; MARF1_RRM1; 1.
DR Pfam; PF01936; NYN; 1.
DR Pfam; PF12872; OST-HTH; 6.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS51644; HTH_OST; 7.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 791..870
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1003..1079
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1099..1173
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1175..1250
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1259..1334
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1335..1410
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1411..1485
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT DOMAIN 1486..1560
FT /note="HTH OST-type"
FT /evidence="ECO:0000259|PROSITE:PS51644"
FT REGION 619..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1742 AA; 192830 MW; 8598E66536A0FBA5 CRC64;
MMEGKGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE YMENKKVAVE
LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS CCAHCPNEPS TSPMRFGGGG
GGSGGTSSLI HPGALLDSQS TRTITCQVGS GFAFQSASSL QNASARNNLA GIASDFPSMC
LESNLSSCKH LPCCGKLHFQ SCHGNVHKLH QFPTLQGCTS AGYFPCSDFT SGAPGHLEEH
ISQSELTPHL CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP
APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL PPIGVFWDIE
NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN KEVIQELNNC QVTVAHINAT
AKNAADDKLR QSLRRFANTH TAPATVVLVS TDVNFALELS DLRHRHGFHI ILVHKNQASE
ALLHHANELI RFEEFISDLP PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG
GKVLSITGCS AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD
KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS TTKNTNVKSL QELCRMESKT
GNRNSEQQQG HLRLVVPAHG NSSATVPMPK NSGVAEPVYK TSQKKENLSA RSVTSSPVEK
KDKEETVFQV SYPSAFSKLV ASRQVSPLLA SQSWSSRSMS PNLLNRASPL AFNIANSSSG
ADCPDPFANG ADVQVSNIDY RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM
ENLQDAIGAV NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF
TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS SQSHDGSSTN
CSPIIFEELE YHEPVCRQHC SNKDFSEHEY DPDSYKIPFV ILSLKTFAPQ VHSLLQTHEG
TVPLLSFPDC YTAEFGDLEV VQENQGGVPL EHFITCVPGV NIATAQNGIK VVKWIHNKPP
PPNTDPWLLR SKSPVGNPQL IQFSREVIDL LKSQPSCVIP ISHFIPSYHH HFAKQCRVSD
YGYSKLIELL EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF
SQAYHWCFSK DWDVTEYGVC ELTDIVSEIP DTTICLSQQD NEMVICIPKR ERTQDEIERT
KQFSKDVVDL LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY YGFTKLLELF EAIPDTLQVL
ECGEEKILTL TEVERFKALA AQFVKLLRSQ KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS
SISALTQKLC HVVKVADVES GRQIQLINRK SLRSLTAQLL VLLMSWEGTT HLSVEELKRH
YESTHNTPLN PCEYGFMTLT ELLKSLPYLV EVFTNDKMEE CVKLTSLYLF AKNVRSLLHT
YHYQQIFLHE FSMAYTKYVG ETLQPKTYGH NSVEELLGAI PQVVWIKGHG HKRIVVLKND
MKSRLSSLGL SPANLENQPS EGERILEVPE PHTASELKLE ADGSGSSHTE QELLRLTDDS
PVDLLCAPVP SCLPSPQLRP DPVILQSADL IQFEEHPQEP SEMMILNQEG KMEIPIPGKS
KTLTSDSSSS CISAAVPLPP CPSSETSESQ LIKDPAESPA KKQPKNRVKL AANFSLAPIT
KL
//
