ID A0A0D9R6V2_CHLSB Unreviewed; 3671 AA.
AC A0A0D9R6V2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Spectrin beta, non-erythrocytic 5 {ECO:0000313|Ensembl:ENSCSAP00000004341.1};
GN Name=SPTBN5 {ECO:0000313|Ensembl:ENSCSAP00000004341.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004341.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004341.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004341.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; AQIB01116244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000004341; -.
DR Ensembl; ENSCSAT00000006130.1; ENSCSAP00000004341.1; ENSCSAG00000008149.1.
DR eggNOG; KOG0517; Eukaryota.
DR GeneTree; ENSGT00940000161549; -.
DR OMA; WANEMHA; -.
DR Proteomes; UP000029965; Chromosome 26.
DR Bgee; ENSCSAG00000008149; Expressed in blood.
DR GO; GO:0045179; C:apical cortex; IEA:Ensembl.
DR GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR GO; GO:0005875; C:microtubule associated complex; IEA:Ensembl.
DR GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR GO; GO:0097381; C:photoreceptor disc membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0032029; F:myosin tail binding; IEA:Ensembl.
DR GO; GO:0002046; F:opsin binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0007041; P:lysosomal transport; IEA:Ensembl.
DR CDD; cd21247; CH_SPTBN5_rpt1; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.60; -; 21.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00435; Spectrin; 27.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 25.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..159
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 177..282
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 3530..3638
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3501..3535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 787..814
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1116..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1416..1479
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2364..2424
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2771..2798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2926..2985
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3029..3095
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3245..3272
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3347..3413
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3453..3480
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3671 AA; 416044 MW; F126A8C43DB7D481 CRC64;
MAGQPQSPRE LLGAAGRCSR RPSTNLQVPP SPSLTVDSQY ETGHIRKLQA RHTQMQEKTF
TKWINNVFQC GQVGIKIRNL YTELADGIHL LRLLELISGE ALPPPSRGRL RVHFLENSSR
ALAFLRAKVP IPLIGPENIV DGDQTLILGL IWVIILRFQI SHISLDKEEF GASAALLSTK
EALLLWCQRK TASYTNVNIT DFSRSWSDGL GFNALIHAHR PDLLDYSSLR PDRPLHNLAF
AFLVAEQELG IAQLLDPEDV AATQPDERSI MTYISLYYHY CSRLHQGQTV QRRLTKILLQ
LQETEALQTQ YEQLVADLLC WIAEKQAQLE VRDFPDSLPA MQQLLAAFTI FRTQEKPPRL
QQRGAAEALL FRLQTALQAQ NRRLFLPHEG LGLAELSQCW AGLEWAEAAR SQALQQRLLQ
LERLETLARR FQRKAALRES FLKDAEQVLD QARALPASLA MAEAASQRLG MLEAGILPQE
GRFQALAEIA DILQQEQYHS WADVARRQEE VTLRWQRLLQ RLQGQRKQVA DMQAVLSLLQ
EVEAASRQLE ELQGLARSTA CGQQLAEVVE LLQRHDLLEA QVSAHGAHVS HLAQQTAELD
SSLGTSVEVL QAKAKTLVQL HQSLVALVRA RRALLEQTLQ RAEFLCNCEE EEAWLKECGQ
RVGNAVLGRD LSQIAGTLQK HKALEAEVHR HQAVCVDLVR RGRDLSARRP PTQPDPGERA
EAVQGAWQLL QTRVVERGAR LQTALLVLQY FADAAEAASW LRERRCSLER ASCGQDQAAA
ETLLRRHVRL ERVLRAFAAE LRRLEEQARA ASARASLFTV KSALSPPGES LRNPGPWSEA
SCHPGDAWKT ALPAEPDPDF DPNTILQTQD HLGQDYESVR ALAERRRARL EEAMALFSFC
SSCRDLQLWL EKHTALLQRV QPQADILEVT QLKYENFLTA LSVGKGLWAE VSSSAEQLRQ
RYPGNSTQIQ RQQEELSQRW GRLEALKREK AVQLAHSADV CSFLQECGPT QVQLRDVLLQ
LEALQPGSSE DTRHTLQLAQ KKTLVLERRV HLLQRVVVKV EESGHAESQP LQGQVETLQG
LLKQVQERVA QQARGQAEAQ ARQSFLQENQ ELLLWAESVQ AQLRSKEESV DVASAQRLLR
EHQDLLEEIH LWQERLQQLD AQSRPMAALD CPDSQEVANT LRLLGQQGQE LKAVWKQRQQ
WLQEGLELQK FSREVVGFTA TCANHESWLH LDNLGEDVRE ALSLLQQHRE FGRLLSTLGP
RAEALWAHGE KLVRSQHPAA HMVREQLQSV QAQWTRLQSR SEQRRRQLLA SLQLQEWKQD
VAELTQWIED KGLMVAHEPS GARRNILRTL RRHEAAESEL LATRRHVEAL QQVGGELLSR
RPGGQEDIQT RLQGLRSRWE ALNRKMTERG DELRQAGQQE QLLRQLQDAK EQLEQLAGAL
QGSETGQDLR SSRKLQKRHH QLENESQTLA AKMAALASQA RGVAASPAIL EETQKHLQRL
ELLQGRLAIQ GLQLQASVEL HQFCDLSNME LSWVAEHMPC SKPTSYAECL NDAQSLHCKH
KELQVEVTAH QGQVQRVLSS GRSLAASGHP QAPHIAEQCQ ELEDRWAELE RACEARARCL
QQAVTFQQYF LDVSELEGWV KEKQPLVSSQ DYGRDEAATL RLIKKHQALR EELTIYWSSM
EELDQRAQTL TGPEAPEQQR VVRERLREQL QALQELAATR DRELEGALKL HEFLRETEDL
QSWLARQKQA AKGGESLGED PEHTLHLCTK FAKFQRQVEM GGQRVAACRL LAEGLLARGH
SAGPMVRQRQ QDLQATWSEL WELTQARGHA LRDAETTLRV HRDLLEVLAQ VKEKAASLPN
NVARDLRGLE AQLRSHQGLE RELVGTKQQL QELLETASRV QKLCPGPQAH AVQQRQQAVM
QAWAVLQRRV EQRRAQLERA RLLARFRTAV RDYASWAARV RQDLQLEESS PEPSSGPLKL
SAHQWLRAEL EAREKLWQQA TQLGQQALLA AGTPTKEVQE KLRALQDQRD QVYQAWARKQ
ERLQAEQQEQ LFLRECGRLE EILAAQEVSL KTSALGSSVE EVEQLIRKHE LFLKVLTAQD
KKEAALRERL KMLRHAQVRD LLPALLQRRV RVKELAESRG HALHASLLMA SFTQAATQAE
DWIQACAQQL KKPIPPGDLR DKLKPLLKHQ AFEAEVQAHE EVMTSVAKKG EALLVQSHPR
VGEVSQRLQG LRKHWEDLRQ AVALRGQELE DRRDFLEFLQ RVDLAEAWIH EKEVMVNVGD
LGQDLEHCLK LRWRLREFRG TSTGDTVGDA RIRSISDLSL QLKNRDPEEV KIICQRRSQL
NSRWASFHGN LLQYQQRLEG ALEIHMLSQE LDSVTERIQE KEALIQALDC GKDLENVQRL
LRKHEELERE VHPIQAQVES LEREVGRLCQ RSPEAAHSLR HRQQEVAESW WQLQSRAQKR
REALDALHQA QKLQATLHEL LVGAQRLRAQ MDMSPAPRSP VEARRMLEVH QERKAELDSW
TDSSSLARST GQRLLTAGHP STPDIRQALA GLEQELSSLE GTWQEHQLQL QQALELQLFL
SSMEKIEHWL SSKEDSLASE GLWDPLAPME PLLWKQKMLE RDLEVQAGKI SALEALAHSL
HQGGHPEAPS ALGRCQAMLL RKEALFRQAG TRRHRLEELR QLQAFLQDSQ EVAAWLREKN
VVALEEGLPD TATLPAQLRK QQNFQAELDA SRHQQQELQR EGQRLLQGGH PASEAIQEQL
QELGALWGEL QDNFQKKVAK LQNACEALRL RRSMEELENW LEPIEVELRA PIGGQALPGV
GELLGTQREL EAAVDKKARQ AEALLGQAQA FVREGHCLAQ DVEEQAQRLL QRFKSLREPL
QERRTALEAR SLLLQFFRDA DEEMAWVQEK LPLATAQDYG QSLSAVRHLQ EQHQNLESEM
NSHEALTRVV LGTGHKLVQA GHFAAHEVAA RVQQLEKAMA HLRAEAARRR LLLQQAQEAQ
QFLTELLEVG SWLAERGHVL DSEDMGHSAE ATQALLRRLE ATKRDLEALS PRLERLQQTA
ALLESRKNAD SPRVLAQLQA VREAHAELLR RVEARGHGLQ EQLQLHQLDR ETLLLDAWLT
TKVATAESQD YGQDLEGVKV LEEKFDAFRK EVQSLGQAKV HALRKLAGTL ERGAPGRYPH
IQAQRSRIEA AWERLDQAIK ARTENLAAAH EVHSFEQAAA ELQGRMQEKT ALMKGEDGGH
SLSSVRTLQQ QHRRLERELA AMEKEVARVQ TEACRLGQLH PMASGGLAKV QEAWATLQAK
AQERGQWLAQ AAQGHAFLGR CQELLAWARE RQELASSEEL AEDVVGAEQL LGQHEELGQE
IRECRLQAQD LRQEGQQLVD NSHFMSPEVT GCLQELEGRL QELEAAWALR RQRCAESWGL
QKLRQRLEQA EAWLACREGL LLKPDYGHSV SDVELLLHRH RDLEKLLAAQ EEKFAQMQKT
EMEQELLLQP QELKPGRAGK LTSFQWRPSG HRGPGAQLAE TRGPQDSKGA PTMEGPLEFK
QHLLPGGRQP SSSSWDSCHG TLQGNSLSLF LDERMAEEKA ASLAALDLTG ARCERLRGCH
GRKHTFSLRL TSGEEILFAA PSEEQAESWW RALGSTAAQS LSPELKAKPV SSPNECTTKD
ARPGCLLRWD T
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