ID A0A0D9R743_CHLSB Unreviewed; 682 AA.
AC A0A0D9R743;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN Name=GFPT2 {ECO:0000313|Ensembl:ENSCSAP00000004432.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004432.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004432.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004432.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
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DR EMBL; AQIB01151323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01151324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01151325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01151326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01151327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R743; -.
DR STRING; 60711.ENSCSAP00000004432; -.
DR Ensembl; ENSCSAT00000006228.1; ENSCSAP00000004432.1; ENSCSAG00000008225.1.
DR eggNOG; KOG1268; Eukaryota.
DR GeneTree; ENSGT00940000156413; -.
DR OMA; GCTAKYW; -.
DR Proteomes; UP000029965; Chromosome 23.
DR Bgee; ENSCSAG00000008225; Expressed in adrenal cortex and 5 other cell types or tissues.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035490; GlmS/FrlB_SIS.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF10; GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 2; 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS51464; SIS; 2.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..287
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 359..498
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 531..672
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 682 AA; 76829 MW; 7320C7DD135B5917 CRC64;
TGIFAYMNYR VPRTRKEIFE TLIKGLQRLE YRGYDSAGVA IDGNNDDVKE RHIQLVKKRG
KVKALDEELY KQDSMDLKVE FETHFGIAHT RWATHGVPSA VNSHPQRSDK GNEFVVIHNG
IITNYKDLRK FLESKGYEFE SETDTETIAK LIKYVFDNRE TEDITFSTLV ERVIQQLEGA
FALVFKSIHY PGEAVATRRG SPLLIGVRSK YKLSTEQIPI LYRTCTLENV KNICKTRMKR
LDSSACLHAV GDKAVEFFFA SDASAIIEHT NRVIFLEDDD IAAAADGKLS IHRVKRSASD
DPSRAIQTLQ MELQQIMKGN FSAFMQKEIF EQPESVFNTM RGRVNFETNT VLLGGLKDHL
KEIRRCRRLI VIGCGTSYHA AVATRQVLEE LTELPVMVEL ASDFLDRNTP VFRDDVCFFI
SQSGETADTL LALRYCKDRG ALTVGITNTV GSSISRETDC GVHINAGPEV GVASTKAYTS
QFISLVMFGL MMSEDRISLQ NRRQEIIRGL RSLPDLVKSI LPLSQVRTRE ADSVLTSESA
VLQMCILYNE MPCRHMSLKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF
AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH
LAVLRGYDVD FPRNLAKSVT VE
//
