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Database: UniProt
Entry: A0A0D9RBD2_CHLSB
LinkDB: A0A0D9RBD2_CHLSB
Original site: A0A0D9RBD2_CHLSB 
ID   A0A0D9RBD2_CHLSB        Unreviewed;      4906 AA.
AC   A0A0D9RBD2;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   30-AUG-2017, entry version 19.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCSAP00000005921};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCSAP00000005921};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000005921, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000005921, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000005921}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAP00000005921}.
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DR   EMBL; AQIB01131431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01131432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01131433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01131434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01131435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01131436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCSAT00000007753; ENSCSAP00000005921; ENSCSAG00000009677.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   Proteomes; UP000029965; Chromosome 25.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029965};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4219   4238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4439   4459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4513   4532       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4649   4670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4707   4728       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4783   4806       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30     85       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       92    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      206    263       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      519    729       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      945   1142       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1257   1482       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3962   3997       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4351   4384       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4906 AA;  557838 MW;  AED5D9D293BE9731 CRC64;
     MLANTVEKSE GQVDVEKWKF MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST
     DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNGS
     LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG EHGEEQRRTV
     HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV TTGKYLSLME DKNLLLMDKE
     KADVKSTAFT FRSSKEKLDV GVRKEVDGMG TSEIKYGDSV CYIQHVDTGL WLTYQSVDVK
     SVRMGSIQRK AIMHHEGHMD DGISLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKA
     KASTVDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE
     CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ FSGSLDWLIS
     RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL LDKHGRNHKV LDVLCSLCVC
     HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF LGVSEGSAQY KKWYYELMVD
     HTEPFVTAEA THLRVGWAST EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART
     VSSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV
     RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL LGPTVSLTQA
     AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL GWQYGPVRDD NKRQHPCLVE
     FSKLPEQERN YNLQMSLETL KTLLALGCHV GISDEHAEDK VKKMKLPKNY QLTSGYKPAP
     MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD
     RTKKSNKDSL REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA EKTYAVKAGR
     WYFEFETVTA GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE HYGRSWQAGD
     VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG FIPVCSLGVA QVGRMNFGKD
     VSTLKYFTIC GLQEGYEPFA VNTNRDITMW LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS
     PCLKVTQKSF GSQNSHTDIM FYRLSMPIEC AEVFSKTVAG GLPGAGLFGP KNDLEDYDAD
     SDFEVLMKTA HGHLVPDRVD KDKEATKPEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTS
     HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF HQYDTGFDLD
     RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR NNNGLEIGCV VDAASGLLTF
     IANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL FKSEHKNPVP
     QCPPRLHVQF LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD
     ILELTEQEEL LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRA
     GYYDLLIDIH LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG IGLSTSLRPR
     MQFSSPSFVS VSNECYQYSP EFPLDILKAK TIQMLTEAVK EGSLHARDPV GGTTEFLFVP
     LIKLFYTLLI MGIFHNEDLK HILQLIEPSV FKEAATPEEE SDTLEKELSV DDAKLQGAGE
     EEAKGGKRPK EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ
     RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH
     EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES DSKKSSTLQQ
     LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING VSVEDTINLL
     ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG
     GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL
     DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCQLL VSKGYPDIGW NPVEGERYLD
     FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA IKIAEDPSRD
     GPSPNSGSSK TLDTEEEEDD TIHMGNAIMT FYAALIDLLG RCAPEMHLIH AGKGEAIRIR
     SILRSLIPLG DLVGVISIAF QMPTIAKDGN VVEPDMSAGF CPDHKAAMVL FLDRVYGIEV
     QDFLLHLLEV GFLPDLRAAA SLDTAALSAT DMALALNRYL CTAVLPLLTR CAPLFAGTEH
     HASLIDSLLH TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN
     EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD ALSQKKYEQE
     LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN FNPQPVDTSN ITIPEKLEYF
     INKYAEHSHD KWSVDKLANG WIYGEIYSDS SKVQPLMKPY KLLSEKEKEI YRWPIKESLK
     TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQVSVDAAHG YSPRAIDMSN VTLSRDLHAM
     AEMMAENYHN IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING
     YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK GEHFPYEQEI
     KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE KEMVTSLFCK LGVLVRHRIS
     LFGNDATSIV NCLHILGQTL DARTVMKTGL ESVKSALRAF LDNAAEDLEK TMENLKQGQF
     THTRNQPKGV TQIINYTTVA LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL
     GTSKSIYVER QRSALGECLA AFAGAFPVAF LETHLDKHNI YSIYNTKSSR ERAALSLPTN
     VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW EHGPENNPER
     AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV KPQLLKTHFL
     PLMEKLKKKA AMVVSEEDHL KAEARGDMSE AELLILDEFT TLARDLYAFY PLLIRFVDYN
     RAKWLKEPNP EAEELFRMVA EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS
     KAAVSDQERK KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD
     TEDEVRDIIR SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD TSDPEKTVER VLDIANVLFH
     LEQKSKRVGR RHYCLVEHPQ RSKKAVWHKL LSKQRKRAVV ACFRMAPLYN LPRHRAVNLF
     LQGYEKSWIE TEEHYFEDKL IEDLAKPGAD PPEEDEGTKR VDPLHQLILL FSRTALTEKC
     KLEEDFLYMA YADIMAKSCH DEEDDDGEEE VKSFEVTGSQ RSKEKEMEKQ KLLYQQARLH
     DRGAAEMVLQ TISASKGETG PMVAATLKLG IAILNGGNST VQQKMLDYLK EKKDVGFFQS
     LAGLMQSCSV LDLNAFERQN KAEGLGMVTE EGSASHFESH RLRTGEKVLQ DDEFTCDLFR
     FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDVIDEQ
     GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD
     SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL
     KLKDLTSSDT FKEYDPDGKG VISKRDFHKA MESHKHYTQS ETEFLLSCAE TDENETLDYE
     EFVKRFHEPA KDIGFNVAVL LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS
     AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ
     LAAQISESDL NERSANKEES EKERPEEQGP RMAFFSILTV KSALFALRYN VLTLMRMLSL
     KSLKKQMKKV KKMTVKDMVT AFFSSYWSIF MTLLHFVASV FRGFFRIICS LLLGGSLVEG
     AKKIKVAELL ANMPDPTQDE VRGDGEEGER KTLEAALPSE DLTDLKELTE ESDLLSDIFG
     LDLKREGGQY KLIPHNPNAG LSDLMSNPVP MPEVQEKFQE QKAKEEEKEE KEETKSEPEK
     AEGEDGEKEE KAKEDKGKQK LRQLHTHRYG EPEVPESAFW KKIIAYQQKL LNYFARNFYN
     MRMLALFVAF AINFILLFYK VSTSSVVEGK ELPTRSSSEN AKVTSLDSSS HRIIAVHYVL
     EESSGYMEPT LRILAILHTV ISFFCIIGYY CLKVPLVIFK REKEVARKLE FDGLYITEQP
     SEDDIKGQWD RLVINTQSFP NNYWDKFVKR KVMDKYGEFY GRDRISELLG MDKAALDFSD
     AREKKKPKKD SSLSAVLNSI DVKYQMWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA
     HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT
     PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF FFVIVILLAI
     IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF
     LMYLINKDET EHTGQESYVW KMYQERCWEF FPAGDCFRKQ YEDQLN
//
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