ID A0A0D9RHX4_CHLSB Unreviewed; 681 AA.
AC A0A0D9RHX4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 4 {ECO:0000313|Ensembl:ENSCSAP00000008213.1};
GN Name=PCSK4 {ECO:0000313|Ensembl:ENSCSAP00000008213.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008213.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008213.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR EMBL; AQIB01152653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01152654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01152655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RHX4; -.
DR STRING; 60711.ENSCSAP00000008213; -.
DR Ensembl; ENSCSAT00000010114.1; ENSCSAP00000008213.1; ENSCSAG00000012070.1.
DR eggNOG; KOG3525; Eukaryota.
DR GeneTree; ENSGT00940000161989; -.
DR OMA; PQKKCAI; -.
DR Proteomes; UP000029965; Chromosome 6.
DR Bgee; ENSCSAG00000012070; Expressed in pituitary gland.
DR GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007340; P:acrosome reaction; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR CDD; cd00064; FU; 1.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF16; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 4; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..681
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345096"
FT DOMAIN 446..578
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 155
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 196
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 370
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 681 AA; 75402 MW; BA266016A9BC1430 CRC64;
VPIALWLLWV LALALLRPRA VGWASVRVPI YVSSWAVRVS QGNREVERLA RKFGFVNLGP
IFPDGQYFHL RHRGVVQQSL TPHWGHRLHL KKDPKVQWFQ QQTLRRRVKR SVVVPTDPWF
SKQWYMNSEA QPDLSVLQAW GQGLSGQGIV VSVLDDGIEK DHPDLWANYD PLASYDFNDY
DPDPQPRYTP SDENRHGTRC AGEVAAMANN GFCGVGVAFN ARIGGVRMLD GTITDVIEAQ
SLSLQPQHIH IYSASWGPED DGRTVDGPGI LTREAFRRGV TKGRGGLGTL FIWASGNGGL
HYDDCNCDGY TNSIHTLSVG STTQQGRVPW YSEACASTLT TTYSSGVATD PQIVTTDLHH
QCTDQHTGTS ASAPLAAGMI ALALEANPFL TWRDMQHLVV RASKPAHLQA EDWRTNGVGR
QVSHHYGYGL LDAGLLVDTA RTWLRTQPQR KCAVRVQNRP TPILPLIYIR KNVSACAGRH
NSIRSLEHVQ AQLTLSYSRR GDLEISLTSP MGTRSTLVAI RPLDVSTEGY NNWVFMSTHF
WDENPQGVWT LGLENKGYYF NTGMLYRYTL LLYGTAEDMT ARPTGPQVTS SACVQRDTEG
LCQAVCDGAA YILGRLCLAY CPPRFFNHTR LVTPRPGHTA ALTLRVCSSC HSSCYTCRGG
SLKDCTSCPP SSTLDQQQGS C
//
