ID A0A0D9RI08_CHLSB Unreviewed; 556 AA.
AC A0A0D9RI08;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Eukaryotic translation initiation factor 2 alpha kinase 2 {ECO:0000313|Ensembl:ENSCSAP00000008247.1};
GN Name=EIF2AK2 {ECO:0000313|Ensembl:ENSCSAP00000008247.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008247.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008247.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008247.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01036442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RI08; -.
DR STRING; 60711.ENSCSAP00000008247; -.
DR Ensembl; ENSCSAT00000010149.1; ENSCSAP00000008247.1; ENSCSAG00000012135.1.
DR eggNOG; KOG1033; Eukaryota.
DR GeneTree; ENSGT00940000160736; -.
DR OMA; LIQMEFC; -.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000012135; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:1902036; P:regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:1902033; P:regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:1900225; P:regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0006412; P:translation; IEA:Ensembl.
DR CDD; cd19904; DSRM_EIF2AK2_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044453; EIF2AK2_DSRM_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR PANTHER; PTHR11042:SF163; INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 9..77
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 100..167
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 266..556
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 192..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 62490 MW; 7A882CEE6582E14C CRC64;
MAGDLAPGFY MEELNKYRQK QGITFSYQEL PNTGPPHDRR FTFRVVTERR EFPEAEGRSK
KEAKNAAAKL AVDILNKESK VVSPFSLTTT SSSEGLSIGN YIGVVNRIAQ KKRLTVNYKQ
CTSGVHGPEG FHYKCKIGEK EYSIGTGSTK QEAKQLAAKL ALLEISEETS VKPDSMSSGS
FAATCDSQSN PLVNNSLASE SSSENDVSAD TSEINSNSGS LNKSSLFTNG LRNNQRKAKR
SLAPTFDPPD MKGPKYTEDA RFGTDFEEIE FISVGGFGQV FKAKHRIDGK TYVIKRVKYN
SKKAEREVKA LAELDHVNIV HYNGCWDGLD YDPEISAYDP ESPDFDPENK KNSLRSKTKC
LFIQMEFCEK GTLEEWIEDR KGKKLDKVLA LELFEQITKG LDYIHSKNII HRDLKPSNIF
LVDTKQIKIG DFGLATSLKN DGKRTRNTGT LRYMSPEQIS LQDYGKEVDL YALGLILAEL
LHVCDTASET SKFFKDLRDG TISDVFDKRE KTLLEKLLSK KPEDRPNTSE ILSTLTTWKK
NPEKKERHTC MAHPIL
//
