ID A0A0D9RJG5_CHLSB Unreviewed; 469 AA.
AC A0A0D9RJG5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=NOP2/Sun RNA methyltransferase 6 {ECO:0000313|Ensembl:ENSCSAP00000008754.1};
GN Name=NSUN6 {ECO:0000313|Ensembl:ENSCSAP00000008754.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008754.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008754.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008754.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|ARBA:ARBA00007494,
CC ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AQIB01160576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008000624.1; XM_008002433.1.
DR AlphaFoldDB; A0A0D9RJG5; -.
DR SMR; A0A0D9RJG5; -.
DR STRING; 60711.ENSCSAP00000008754; -.
DR Ensembl; ENSCSAT00000010665.1; ENSCSAP00000008754.1; ENSCSAG00000012571.1.
DR GeneID; 103237969; -.
DR KEGG; csab:103237969; -.
DR CTD; 221078; -.
DR eggNOG; KOG1122; Eukaryota.
DR GeneTree; ENSGT00940000155370; -.
DR OMA; YQGAMLY; -.
DR OrthoDB; 1077100at2759; -.
DR BioGRID-ORCS; 103237969; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000012571; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:0002946; P:tRNA C5-cytosine methylation; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21150; PUA_NSun6-like; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22807:SF34; TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR PROSITE; PS50890; PUA; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 141..466
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 373
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 242..248
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 266
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 293
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 323
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 469 AA; 51794 MW; 1235B3143E4E75AF CRC64;
MSIFPKISLR PEVENYLKEG FVNKEIVTAL GKQEAERKFE TLLKHLSHPP SFTTVRVNTH
LASVQHVKNL LLDELQKQFN GLSIPILQHP DLQDVLLIPV IGPRKNIKKQ QCEAIVGAQC
GNAVLRGAHV YAPGIVSASK FMKAGDVVSV YSDIKGKCKK GAREFDGTKV FLGNGISELS
RKEIFSGLPE LKGMGIRMTE PVYLSPSFDN VLPRYLFLQN LPSALVTHVL NPQPGEKILD
LCAAPGGKTT HIAALMHDQG EVIALDKIFS KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS LKELASYQPL QRKLFTAAVQ
LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE PQIGGEGMRG AGLSCEQLKQ
LQRFDPSAVP LPDTDMDSLR EARREDMLRL ANKDSIGFFV AKFVKCKST
//
