ID A0A0D9RJP6_CHLSB Unreviewed; 1106 AA.
AC A0A0D9RJP6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSCSAP00000008835.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSCSAP00000008835.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008835.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008835.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AQIB01138034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RJP6; -.
DR STRING; 60711.ENSCSAP00000008835; -.
DR Ensembl; ENSCSAT00000010746.1; ENSCSAP00000008835.1; ENSCSAG00000012704.1.
DR eggNOG; ENOG502S4A4; Eukaryota.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000012704; Expressed in blood and 1 other cell type or tissue.
DR GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140608; F:cysteine-type endopeptidase activator activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1904784; P:NLRP1 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 332..641
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 160..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 124387 MW; 253219298DCD6A8C CRC64;
MAGGAWGRLA CYLELLKKEE LKEFQLLFTS KVHSSGSSGE TPARPEKTSG MEVASYLVAQ
YGEQRAWDLA LRTWEQMGLW SLCTQAQEGA GYSPSFPYSP IEPHLGSPSQ PTSTAVLRPW
NRELPAECTQ GSERRVLRQL PDTSGRRWRE ISSSFLYQAL PSSPDLESPS QESPNAPTST
AVLASWRSPP QPSLAPREQE APGTQWPLDE TSGNYYTGIR EKEREESEKG RPPWEAAVGT
PPQVHASLQP PRHPWEPSAR ESLCSTWSWN NEDLNQNFTQ LLLLQRPHPR SQKPLVKGSW
PHDVEEDVEE DRGRLIEIRD LFGPGLDPQE PHIVILQGAA GIGKSTLARQ VREAWGRGQL
YGDRFQHVFY FSCRDLAQCK VVSLAELIGK DWTAAQAPIR QILSRPERLL FILDGVDEPR
WVLQEPSSEL CLHWSQPQPA DALLGSLLGK TILPEASFLI TARTTALQNL IPSLEQARWV
EVLGFSESSR REYFYKYFTD ERQAIRAFGL IKSNKELWAL CLVPWVSWLA CTCLMEQMKR
KEELTLTSKT TTTLCLHYLS QALQAQPLGP QLGDVCSLAA EGIWQKKTLF SRDDLRKHEL
DGAIISTLLK MGILQEHPIP LSYSFIHLCF QEFFAAMSYA LEDKKGRGKH ANCIIDLEKL
LEAYGTHGLF GAPTTRFLLG LLSDEGERAM ENIFNCRRSQ GRNLMQWVPC LRPLLQPHSL
DFLHCLYETQ NKMFLTHMMA DFQEMGMCVE TDMELLVCTF CIQFCRHVKK LQLIEGRQHR
PAWSPTGIVL FRWVPVTDAY WEILFSILKV TRNLKELDLS GNSLSHSAVK SLCKTLRRPR
CLLETLRLAS CGLTAQDCKD LASGLRGNQN LTVLDLSFNV LTDAGARHLC QRLSWTCCTL
QRLRMGFCHV TSGCCQDLAS VLSASPFLME LDLQQNNLGD TGVRLLCEGL RHPACQLTRL
GLDQTTLSDE MRQELRALEQ KKPQLLIFSR WKPTGMIPNE GLGTGETTNS TSSRKRQRLG
SETESSHVAQ ADFKLLDWSN PPAKASQSAG ITEGSSPEVE QLEPLCLPSP ASLGDQDTPL
GTDDDFWGPM GPVATEVVDK ERSLYR
//
