ID A0A0D9RJY4_CHLSB Unreviewed; 1493 AA.
AC A0A0D9RJY4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Pleckstrin homology, MyTH4 and FERM domain containing H2 {ECO:0000313|Ensembl:ENSCSAP00000008923.1};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSCSAP00000008923.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008923.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008923.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008923.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01038014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01038023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007968987.1; XM_007970796.1.
DR STRING; 60711.ENSCSAP00000008923; -.
DR Ensembl; ENSCSAT00000010836.1; ENSCSAP00000008923.1; ENSCSAG00000012860.1.
DR KEGG; csab:103220386; -.
DR eggNOG; KOG0248; Eukaryota.
DR GeneTree; ENSGT00940000157675; -.
DR OMA; WCILIGK; -.
DR OrthoDB; 4538469at2759; -.
DR BioGRID-ORCS; 103220386; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000012860; Expressed in fibroblast and 6 other cell types or tissues.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 703..797
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 811..919
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 955..1110
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1121..1451
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 202..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 212..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1493 AA; 168201 MW; 4177E1B3EF353AE4 CRC64;
MAELSESEGP VDWKERCVAL ESQLMKFRVQ ASKIRELLAE KMQQLERQVI DAERQAEKAF
QQVQVMEDKL KAANIQTSES ETRLYNKCQD LELLIQEKDD IIQNLELQLE EQKQIRIQEA
KIIEEKAAKI KEWVTVKLNE LELENQNLRL INQNQTEEIR TMQSKLQEVQ GKKSSTVSTL
KLSEGQRLSS LTFGCFLSRA RSPPQVVKSE EMSKISSKEP EFTEGKDMEE MEIPEKSVDN
QVLEHNRGQR TLHQTPCGSE QNRKTRTSFA TEGGVSQNSG APVSDWSSDE EDGNKGRSKS
RCTSTLSSHT SEEGVRCSRM GSEMYLTASD DSSSIFEEET FGVKRPEHKK LYSWQQEAQW
KALNSPLGKG NSESSKKEQD SSSDELNKKF QSQRLDYSSS SSEANTPSPI LTPALMPKHP
NSLSGKGTQL VPSSHLPPPK LRIPNVFSIS VALAKRHLSQ PQLSSDRMFG TNRNAISMIR
PLRPQETDLD LVDGDSAEVL ENMDTSCDDG LFSYDSLDSP NSDDQENCDS AKKVACSKPP
TPPLHRFPSW ESRIYAVAKS GIRMSEAFNM ENVNKNSVAA LSYTTSGLYT SLIYKNMTTP
VYTTLKGKAT QISNSPFLDD SSGSEEEDSS RSSSRTSESD SRSRSGPGSP RAMKRGVSLS
SVASESDYAI PPDAYSTDTE YSQPEQKLPK TCSSSSDNGK NEPLEKSGYL LKMSGKVKSW
KRRWFVLKGG ELLYYKSPSD VIRKPQGHIE LSASCSILRG DNKQTVQLTT EKHTYYLTAD
SPNILEEWIK VLQNVLRVQA ANPLSLQPEG KPTVKGLLTK VKHGYSKRVW CTLIGKTLYY
FRSQEDKFPL GQIKLWEAKV EEVDRSCDSD EDYEASGRSL LSTHYTIVIH PKDQGPTYLL
IGSKHEKDTW LYHLTVAAGS NNVNVGSEFE QLVCKLLNID GEPSSQIWRH PTLCHSKEGI
ICPLTTLPSE ALQTEAIKLF KTCQLFINAA VDSPAIDYHI SLAQSALQIC LTHPELQNEI
CCQLIKQTRR RQPQNQPGPL QGWQLLALCV GLFLPHHPFL WLLRLHLKRN ADSRTEFGKY
AIYCQRCVER TQQNGDREAR PSRMEILSTL LRNPYHHSLP FSIPVHFMNG IYQVVGFDAS
TTVEEFLNTL NQDTGMRKPA QSGFALFTDD PSGRDLEHCL QGNIKICDII SKWEQASKEQ
QPGKCEGTRT VRLTYKNRLY FSVQARGETD REKLLLMYQT NDQIINGLFP LNKDLALEMA
ALLAQVEIGD FERPFSTPAG HVTHQCKANQ TLKQVIEKFY PKRYRDGCSE EQLRQLCQRL
STRWMALRGH SAADCVRIYL TVARKWPFFG AKLFLAKPIT PSSLGSTFMW LAVNEDGLSL
LEYNSMRLIV SYVYKSLMTF GGYQDDFMVV FNNTHSKDTP TEKLLFAMAK PKILEITLLI
ASYINNFHQQ KAAFHHLSAP ALLSAQTRGP QARMMGSQPL LSSSRPTKGP TLL
//