ID A0A0D9RQ43_CHLSB Unreviewed; 1187 AA.
AC A0A0D9RQ43;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=MAP3K15 {ECO:0000313|Ensembl:ENSCSAP00000010732.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010732.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000010732.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000010732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR EMBL; AQIB01132661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01132670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RQ43; -.
DR STRING; 60711.ENSCSAP00000010732; -.
DR Ensembl; ENSCSAT00000012701.1; ENSCSAP00000010732.1; ENSCSAG00000014608.1.
DR eggNOG; KOG4279; Eukaryota.
DR GeneTree; ENSGT00940000159562; -.
DR OMA; MQPNWDS; -.
DR Proteomes; UP000029965; Chromosome X.
DR Bgee; ENSCSAG00000014608; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF363; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 526..782
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 813..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1054..1088
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 813..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 555
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1187 AA; 135413 MW; A99C8290B62D129C CRC64;
MSDVSRQPSL FYHLGVRESF DMANNVILYH DTDADTALSL KDMVTQKNTA SSGNYYFIPY
IVTPCADYFC CESDAQRRAS EYMQPNWDNI LGPLCVPLVD RFISLLKDIH VTSCVYYKET
LLNDIRKARE KYQGEELAKE LARIKLRMDN TEVLTSDIII NLLLSYRDIQ DYDAMVKLVE
TLEMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQIM LQVLQSCDHP GPDMFCLCGR
IYKDIFLDSD CKDDTSRDSA IEWYRKGFEL QSSLYSGINL AVLLIVAGQQ FETSLELRKI
GVRLNSLLGR KGSLEKMNNY WDVGQFFSVS MLASDVGKAV QAAERLFKLK PPVWYLRSLV
QNLLLIRRFK KPIIEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS
INNEAEERTV SLWHVSPTEM KQMHEWNFIA SSIKGISLSK FDERCCFLYV HDNSDDFQIY
FSTEEQCSRF FSLVKEMITN TAGSTVELEG ETDGDTLEYE YDHDANGERV VLGKGTYGIV
YAGRDLSNQV RIAIKEIPER DSRYSQPLHE EIALHKYLKH RNIVQYLGSV SENGYIKIFM
EQVPGGSLSA LLRSKWGPMK EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG
VVKISDFGTS KRLAGVNPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT
SKPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPHKR ATTAELLREG
FLRQVNKGKK NRIAFKPSEG PRGVVLALPT QGEPMATSSS EHSSVSPDSD AQPDALFERT
RAPRHHLGHL LSVPDESSAL EDRSLASSPE DRDPGLFLLR KDSERRAILY KILWEEQNQV
ASNLQECVAQ SSEELHLSVG HIKQIIGILR DFIRSPEHRV MATTISKLKV DLDFDSSSIS
QIHLVLFGFQ DAVNKILRNH LIRPHWMFAM DNIIRRAVQA AVTILIPELQ AHFEPTCETE
GVDKDMDEAE EGYPPAARPG QEAQPHQQHL SLQLGELRQE TNRLLEHLVE KEREYQNLLR
QTLEQKTQEL YHLQLKLKSN CITENPAGPY GQRTDKELID WLRLQGADAK TIEKIVEEGY
TLSDILNEIT KEDLRYLQLR GGLLCRLWSA VSQYRRAQEA SETKDEA
//
