ID A0A0D9RRK0_CHLSB Unreviewed; 894 AA.
AC A0A0D9RRK0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=PIGG {ECO:0000313|Ensembl:ENSCSAP00000011239.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011239.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011239.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011239.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01147730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01147731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01147732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008016404.1; XM_008018213.1.
DR RefSeq; XP_008016405.1; XM_008018214.1.
DR AlphaFoldDB; A0A0D9RRK0; -.
DR STRING; 60711.ENSCSAP00000011239; -.
DR Ensembl; ENSCSAT00000013233.1; ENSCSAP00000011239.1; ENSCSAG00000015139.1.
DR GeneID; 103246520; -.
DR CTD; 54872; -.
DR eggNOG; KOG2125; Eukaryota.
DR GeneTree; ENSGT00910000144269; -.
DR OMA; RVKFGHD; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR BioGRID-ORCS; 103246520; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 27.
DR Bgee; ENSCSAG00000015139; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051267; F:CP2 mannose-ethanolamine phosphotransferase activity; IEA:Ensembl.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 343..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 560..876
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 894 AA; 98896 MW; 36DE1103D5C56608 CRC64;
MPYTTYLVEK GASHSFVAEA KPPTVTMPRI KALMTGSLPG FVDVVRNLNS PALLEDSVIR
QAKTAGKRII FYGDETWVKL FPKHFVEYDG TTSFFVSDYT EVDNNVTRHL DKVLKRGDWD
MLILHYLGLD HIGHISGPNS PLIGHKLSEM DSVLMKIHTS LQSKERETPL PNLLVLCGDH
GMSETGSHGA SSMEEVNTPL ILISSAFERK PGDIRHPKRV QQTDVAATLA IALGLPIPKD
SVGSLLFPVV EGRPMREQLR FLHLNTVQLS KLLQENVPSY EKDPGFEQFK MSERLHGNWI
RLYLEEKHSE VLFNLGSKVL RQYLAALKTL SLSLSTQVAQ YDMYSMMVGT VVVLEVLTLL
LLSVPQALHR KAELEVPLAS PGFSLLFYLV ILVLSAVHVI VCTSAESSCY FCGLSWLAAG
GVMVLASALL CVIVSVLTNM LVGGNTSRKN PVPPSSRWSE LDLLILLGTA GHVLSLGASS
FVEEEHQTWY FLVNTLCLAL SQETYRNYFL GDDSEPPCGL RVEQGLDGAT AAWQDGPACD
ALERDKGHRS PSASQVLRGH EKWMVLASPW LILACCRLLR SLNQTGVQWA HRPDLGHWLT
SSDHKAELSV LAAISLLVVF VLVQRGCSSV SKAALALGLL GVYCYRAAIG SVRFPWRPDS
KDISKGIIEA RFVYVFVLGI LFTGTKDLLK SQVIAADFQL KTVGLWEIHS GLVLLAALLF
RPHNLPVLAF SLLIQTLMTK FIWKPLRHDA AEITVMHYWF GQAFFYFQGN SNNIATVDIS
AGFVGLDTYV EIPAVLLTAF GTYAGPVLWA SHLVHFLSSE TRSSSALSHA CFCYALICSI
PVSTYIVLVT SLRYHLFIWS VFSPKLLYEG MHLLITAAVC VFFTAMDQTR LTQS
//
