ID A0A0D9RSQ6_CHLSB Unreviewed; 411 AA.
AC A0A0D9RSQ6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Potassium two pore domain channel subfamily K member 2 {ECO:0000313|Ensembl:ENSCSAP00000011645.1};
GN Name=KCNK2 {ECO:0000313|Ensembl:ENSCSAP00000011645.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011645.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011645.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011645.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; AQIB01130113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01130114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007986642.1; XM_007988451.1.
DR AlphaFoldDB; A0A0D9RSQ6; -.
DR SMR; A0A0D9RSQ6; -.
DR STRING; 60711.ENSCSAP00000011645; -.
DR Ensembl; ENSCSAT00000013654.1; ENSCSAP00000011645.1; ENSCSAG00000015559.1.
DR GeneID; 103230096; -.
DR CTD; 3776; -.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00940000156560; -.
DR OMA; MTPCKRT; -.
DR OrthoDB; 600333at2759; -.
DR BioGRID-ORCS; 103230096; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 25.
DR Bgee; ENSCSAG00000015559; Expressed in adrenal cortex and 5 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF21; POTASSIUM CHANNEL SUBFAMILY K MEMBER 2; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 50..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..180
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 223..297
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 411 AA; 45495 MW; FDE40CAB21B42A1C CRC64;
MAAPDLLDPK SAAQNSKPRL SFSTKPTVLA SRVESDTTIN VMKWKTVSTI FLVVVLYLII
GATVFKALEQ PHEISQRTTI VIQKQTFISQ HSCVNSTELD ELIQQIVAAI NAGIIPLGNT
SNQISHWDLG SSFFFAGTVI TTIGFGNISP RTEGGKIFCI IYALLGIPLF GFLLAGVGDQ
LGTIFGKGIA KVEDTFIKWN VSQTKIRIIS TIIFILFGCV LFVALPAIIF KHIEGWSALD
AIYFVVITLT TIGFGDYVAG GSDIEYLDFY KPVVWFWILV GLAYFAAVLS MIGDWLRVIS
KKTKEEVGEF RAHAAEWTAN VTAEFKETRR RLSVEIYDKF QRATSIKRKL SAELAGNHNQ
ELTPCRRTLS VNHLTSERDV LPPLLKTESI YLNGLTPHCA GEEIAVIENI K
//
