ID A0A0D9RSY1_CHLSB Unreviewed; 357 AA.
AC A0A0D9RSY1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Transmembrane protein 129, E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSCSAP00000011720.1};
GN Name=TMEM129 {ECO:0000313|Ensembl:ENSCSAP00000011720.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011720.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011720.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM129 family.
CC {ECO:0000256|ARBA:ARBA00007332}.
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DR EMBL; AQIB01147678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008016341.1; XM_008018150.1.
DR AlphaFoldDB; A0A0D9RSY1; -.
DR STRING; 60711.ENSCSAP00000011720; -.
DR Ensembl; ENSCSAT00000013730.1; ENSCSAP00000011720.1; ENSCSAG00000015634.1.
DR GeneID; 103246481; -.
DR KEGG; csab:103246481; -.
DR CTD; 92305; -.
DR eggNOG; KOG3899; Eukaryota.
DR GeneTree; ENSGT00390000013284; -.
DR OMA; FCVLDVC; -.
DR OrthoDB; 2878268at2759; -.
DR BioGRID-ORCS; 103246481; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 27.
DR Bgee; ENSCSAG00000015634; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR InterPro; IPR018801; TM129.
DR PANTHER; PTHR31322; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR PANTHER; PTHR31322:SF2; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR Pfam; PF10272; Tmpp129; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 357 AA; 39888 MW; 5F630DADB57C5D3B CRC64;
MDSPEVTFTL AYLVFAVCFV FTPNEFHAAG LTVQNLLSGW LGSEDAAFVP FHLRRTAATL
LCHSLLPLGY YVGMCLAASE KRFHSPAWRL FLLLAVTLPS VACILIYYWS RGRWARHPLA
RTLALYALPQ SGWQAVASSI NTEFRRIDKF ATGAPGARVI VTDVWVMKVT TYRVHVAQQQ
DVHLTVTESR QHELSPDSNL PVQLLTIRVA SANPAVQAFD IRLNSTEYGE LCEKLRAPIR
RAAHVVIHQS LGDLFLETFA SLVEVNPAYS VPSSQELEAC IGCMQTRASV KLVKTCQEAA
AGECQQCYCR PMWCLTCMGK WFASRQDPLR PDTWLASRVP CPTCRARFCI LDVCTVR
//
