ID A0A0D9RTK1_CHLSB Unreviewed; 3133 AA.
AC A0A0D9RTK1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Huntingtin {ECO:0000313|Ensembl:ENSCSAP00000011940.1};
GN Name=HTT {ECO:0000313|Ensembl:ENSCSAP00000011940.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011940.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011940.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011940.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in microtubule-mediated transport or vesicle
CC function. {ECO:0000256|ARBA:ARBA00002907}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the huntingtin family.
CC {ECO:0000256|ARBA:ARBA00007153}.
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DR EMBL; AQIB01147609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01147610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01147611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008016253.1; XM_008018062.1.
DR STRING; 60711.ENSCSAP00000011940; -.
DR Ensembl; ENSCSAT00000013958.1; ENSCSAP00000011940.1; ENSCSAG00000015865.1.
DR KEGG; csab:103246449; -.
DR eggNOG; ENOG502QR1D; Eukaryota.
DR GeneTree; ENSGT00390000015863; -.
DR OMA; PNKMEEP; -.
DR OrthoDB; 6903at2759; -.
DR BioGRID-ORCS; 103246449; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 27.
DR Bgee; ENSCSAG00000015865; Expressed in prefrontal cortex and 7 other cell types or tissues.
DR GO; GO:0005776; C:autophagosome; IEA:Ensembl.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016234; C:inclusion body; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0099524; C:postsynaptic cytosol; IEA:Ensembl.
DR GO; GO:0099523; C:presynaptic cytosol; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0005522; F:profilin binding; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:1905337; P:positive regulation of aggrephagy; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR GO; GO:1904504; P:positive regulation of lipophagy; IEA:Ensembl.
DR GO; GO:1901526; P:positive regulation of mitophagy; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:1905289; P:regulation of CAMKK-AMPK signaling cascade; IEA:Ensembl.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl.
DR GO; GO:0042297; P:vocal learning; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR048412; Htt_bridge.
DR InterPro; IPR048413; Htt_C-HEAT_rpt.
DR InterPro; IPR048411; Htt_N_HEAT_rpt-1.
DR InterPro; IPR000091; Huntingtin.
DR InterPro; IPR028426; Huntingtin_fam.
DR InterPro; IPR024613; Huntingtin_N_HEAT_rpt-2.
DR PANTHER; PTHR10170:SF10; HUNTINGTIN; 1.
DR PANTHER; PTHR10170; HUNTINGTON DISEASE PROTEIN; 1.
DR Pfam; PF20925; Htt_bridge; 1.
DR Pfam; PF20927; Htt_C-HEAT; 1.
DR Pfam; PF12372; Htt_N-HEAT; 1.
DR Pfam; PF20926; Htt_N-HEAT_1; 1.
DR PRINTS; PR00375; HUNTINGTIN.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2322..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2625..2653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2325..2340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3133 AA; 346436 MW; F26543E3AFFB8FDD CRC64;
MATLEKLMKA FESLKSFQQQ QQQQQQQPPP PPPPPPPPPP PQLPQPPQAQ PMLPQPQPPP
PPPPPPPGPA VAEEPLHRPK KELSATKKDR VNHCLTICEN IVAQSVRNSP EFQKLLGIAM
ELFLLCSDDA ESDVRMVADE CLNKVIKALM DSNLPRLQLE LYKEIKKNGA PRSLRAALWR
FAELAHLVRP QKCRPYLVNL LPCLSRTSKR PEESVQETLA AAVPKIMASF GNFANDNEIK
VLLKAFIANL KSSSPTIRRT AAGSAVSICQ HSRRTQYFYS WLLNVLLGLL VPVEEEHSTL
LILGVLLTLR YLVPLLQQQV KDTSLKGSFG VTRKEMEVSP SAEQLVQVYE LTLHHTQHQD
HNVVTGALEL LQQLFRTPPP ELLQALTTVG GIGQLTAAKE ESGGRSRSGS IVELIAGGGS
SCSPVLSRKQ KGKVLVGEEE ALEDDSESRS DVSSSAFAAS VKDDISGELA TSSGVSTPGS
AGHDIITEQP RSQHTLQADS VDLASCDLTS SATDGDEEDI LSHSSSQVSA VPSDPAMDLN
DGTQASSPIS DSSQTTTEGP DSAVTPSDSS EIVLDGTDNQ YLGLQIGQPQ DEDEEATGVL
PDEASEAFRN SSMALQQAHL LKNMSHSRQP SDSSVDKFVL RDEATEPGDQ ENKPCRIKGD
IGQSTDDDSA PLVHCVRLLS ASFLLTGGKN VLVPDRDVRV SVKALALSCV GAAVALHPES
FFSKLYKVPL DTTEYPEEQY VSDILNYIDH GDPQVRGATA ILCGTLICSI LSRSRFHVGD
WMGAIRTLTG NTFSLADCIP LLRKTLKDES SVTCKLACTA VRHCVMSLCS SSYSELGLQL
IIDVLTLRNS SYWLVRTELL ETLAEIDFRL VSFLEAKAEN LHRGAHHYTG LLKLQERVLN
NVVIHLLGDE DPRVRHVAAA SLIRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET
QPPSHFSVST ITRIYRGYNL LPSITDVTME NNLSRVIAAV SHELITSTTR ALTFGCCEAL
CLLSTAFPVC IWSLGWHCGV PPLSASDESR KSCTVGMATM ILTLLSSAWF PLDLSAHQDA
LILAGNLLAA SAPKSLRSSW ASEEEANPAA TKQEEVWPAL GDRALVPMVE QLFSHLLKVI
NICAHVLDDV APGPAIKAAL PSLTNPPSLS PIRRKGKEKE PGEQASVPLS PKKGSEASAA
SRQSDTSGPV TTSKSSSLGS FYHLPSYLKL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS
ALDVLSQILE LATLQDIGKC VEEILGYLKS CFSREPMMAT VCVQQLLKTL FGTNLASQFD
GLSSNPSKSQ GRAQRLGSSS VRPGLYHYCF MAPYTHFTQA LADASLRNMV QAEQEHDTSG
WFDVLQKVST QLKTNLTSVT KNRADKNAIH NHIRLFEPLV IKALKQYTTT TSVQLQKQVL
DLLAQLVQLR VNYCLLDSDQ VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY
HSKQIIGIPK IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE
VVVSMLLRLI QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ IADIILPMLA KQQMHIDSHE
ALGVLNTLFE ILAPSSLRPV DMLLRSMFVT PNTMASVSTV QLWISGILAI LRVLISQSTE
DIVLSRIQEL SFSPYLISCP VINRLRDGDS NSALEEHSEG KQIKNLPEET FSRFLLQLVG
ILLEDIVTKQ LKVEMSEQQH TFYCQELGTL LMCLIHIFKS GMFRRITAAA TRLFRSDGCG
GSFYTLDSLN LRARSMITTH PALVLLWCQI LLLVNHTDYR WWAEVQQTPK RHSLSSTKLL
SPQMSGEEED SDLAAKLGMC NREIVRRGAL ILFCDYVCQN LHDSEHLTWL IVNHIQDLIS
LSHEPPVQDF ISAVHRNSAA SGLFIQAIQS RCENLSTPTT LKKTLQCLEG IHLSQSGAVL
TLYVDRLLCT PFRVLARMVD ILACRRVEML LAANLQSSMA QLPMEELNRI QEYLQSSGLA
QRHQRLYSLL DRFRLSTMQD SLSPSPPVSS HPLDGDGHVS LETVSPDKDW YIHLVKSQCW
TRSDSALLEG AELVNRIPAE DMSAFMMNSE FNLSLLAPCL SLGMSEISGG QKSPLFEAAR
EVTLARVSST VQQLPAVHHV FQSDLPAEPA AYWSKLNDLF GDAALYQSLT TLARALAQYL
VVVSKLPSHL HLPPEKEKDT MKFVVATLEA LSWHLIHEQI PLSLDLQAGL DCCCLALQLP
GLWSVVSSAE FVTHACSLIH CVHFILEAVA VQPGEQLLSP ERRTNTPKAI REEEEEVDPN
TQNPKYITAA CEMVAEMVES LQSVLALGHK RNSGVPAFLT SVLRNIVVSL ARLPLVNSYT
RVPPLVWKLG WSPKPGGDFG TAFPEIPVEF LQEKEVFKEF IYRINTLGWT SRTQFEETWA
TLLGVLVTQP LVMEQEESPP EEDTERTQIN VLAVQAITSL VLSAMTVPVA GNPAVSCLEQ
QPRNKPLKAL DTRFGRKLSI IRGIVEQEIQ AMVSKRENIA THHLYQAWDP VPSLSPATTG
ALISHEKLLL QINPERELGS VSYKLGQVSI HSVWLGNSIT PLREEEWDEE EEEEADAPAP
SSPPTSPVNS RKHRAGVDIH SCSQFLLELY SRWILPSNSA RRTPAILISE VVRSLLVVSD
LFTERNQFEL MYVTLTELRR VHPSEDEILA QYLVPATCKA AAVLGMDKVV AEPVSRLLES
TLRSSHLPSR VGALHGILYV LECDLLDDTA KQLIPVISDY LLSNLKGIAH CVNIHSQQHV
LVMCATAFYL IENYPLDVGP EFSASIIQMC GVMLSGSEES TPSIIYHCAL RGLERLLLSE
QLSRLDAESL VKLSVDRVNV HSPHRAMAAL GLMLTCMYTG KEKVSPGRTS DPNPAAPDSE
SVIVAMERVS VLFDRIRKGF PCEARVVARI LPQFLDDFFP PQDIMNKVIG EFLSNQQPYP
QFMATVVYKV FQTLHSTGQS SMVRDWVMLS LSNFTQRTPV AMATWSLSCF FVSASTSPWV
AAILPHVISR MGKLEQVDVN LFCLVATDFY RHQIEEELDR RAFQSVFEVV AAPGSPYHRL
LTCLRNVHKV TTC
//
