ID A0A0D9RX25_CHLSB Unreviewed; 575 AA.
AC A0A0D9RX25;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Interleukin 1 receptor like 2 {ECO:0000313|Ensembl:ENSCSAP00000013164.1};
GN Name=IL1RL2 {ECO:0000313|Ensembl:ENSCSAP00000013164.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013164.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013164.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013164.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; AQIB01138485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RX25; -.
DR STRING; 60711.ENSCSAP00000013164; -.
DR Ensembl; ENSCSAT00000015219.1; ENSCSAP00000013164.1; ENSCSAG00000017133.1.
DR eggNOG; ENOG502QWEU; Eukaryota.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; CHLNFPQ; -.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000017133; Expressed in fibroblast and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR CDD; cd05757; Ig2_IL1R-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF9; INTERLEUKIN-1 RECEPTOR-LIKE 2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346219"
FT TRANSMEM 336..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 381..536
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 575 AA; 65592 MW; 55B6762429EFFE8C CRC64;
MWSLLLCGLS IALPLSVTAD GCNDIFMKNE MLSASQPFAF NCTFPPITTG EVSVTWYKNS
SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR DSCHRIHVNL TVFEKQWCDT
SVKGLPNVSD EYKQILHLGK DDSLTCHLHF PKSCVLGPIK WYKDCNEITG ERFTVLETRL
LVSNVSAEDR GHYACQVILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNNSIEVQ
LGTTLIVDCN ITDTKDNTNL RCWRVNNTLV DDYYNESKRI REGVETHASF REHNLYTVNI
TFLEVKMEDY GLPFMCHAGV SAAYIMLQLP APDFRAYLIG GLIAFLAVAV SVVYIYSIFK
IDIVLWYRSA FCSTETLEDG KLYDAYVLYP KPHRESQRRA VDTLVLKILP EVLERQCGYK
LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFC LLKNLSEEQI AVYNALIQDG
MKVILIELEK IEDYTAMPES IQYIRQKHGV IRWHGDFTEQ SQCVKTKFWK TVRYHMPPRR
CRPSPAVQLP QHMPCYRTTG PKLGSRRKKC TLKTG
//
