ID A0A0D9S0R4_CHLSB Unreviewed; 578 AA.
AC A0A0D9S0R4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=NADPH oxidase 4 {ECO:0000313|Ensembl:ENSCSAP00000014453.1};
GN Name=NOX4 {ECO:0000313|Ensembl:ENSCSAP00000014453.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000014453.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000014453.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000014453.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AQIB01098603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9S0R4; -.
DR STRING; 60711.ENSCSAP00000014453; -.
DR Ensembl; ENSCSAT00000001628.1; ENSCSAP00000014453.1; ENSCSAG00000003604.1.
DR eggNOG; KOG0039; Eukaryota.
DR GeneTree; ENSGT00940000159621; -.
DR OMA; AFWYTHQ; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000003604; Expressed in fibroblast.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0072341; F:modified amino acid binding; IEA:Ensembl.
DR GO; GO:0016174; F:NAD(P)H oxidase H2O2-forming activity; IEA:Ensembl.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0016175; F:superoxide-generating NAD(P)H oxidase activity; IEA:Ensembl.
DR GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0003015; P:heart process; IEA:Ensembl.
DR GO; GO:0050667; P:homocysteine metabolic process; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000573; P:positive regulation of DNA biosynthetic process; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042554; P:superoxide anion generation; IEA:Ensembl.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF209; NADPH OXIDASE 4; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 303..418
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 578 AA; 67051 MW; D59B88AFEFE52ECC CRC64;
MAVSWRSWLA NEGVKHLCLL IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS
ASVLNLNCSL ILLPMCRILL AFLRGSQKVP SRRTRRLLDK SRFHITCGVT ICIFSGVHVA
AHLVNALNFS VNYSEDFVEL NAARYRNEDP RKLLFTTVPG LTGVCMVVVL FLMITASTYA
IRVSNYDIFW YTHNLFFVFY MLLMLHVSGG LLKYQTNLDT HPPGCINLNR TSSQNISLPE
YFSEHFHEPF PEEFSKPEEF TQNTFVKICM EEPRFQANFP QTWLWISGPL CLYCAERLYR
YIRSNKPVTI ISVISHPSDV MEIRMVKENF KARPGQYIIL HCPSVSALEN HPFTLTMCPT
ETKATFGVHL KIVGDWTERF RDLLLPPSSQ DSEILPFIQS RNYPKLYIDG PFGSPFEESL
NYEVSLCVAG GIGVTPFASI LNTLLDDWKP YKLRRLYFIW VCRDIQSFRW FADLLCMLHN
KFWQENRPDY VNIQLYLSQT DGIQQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS
//
