UniProt: A0A0D9S6U7

Database: UniProt
Entry: A0A0D9S6U7_CHLSB

LinkDB:  A0A0D9S6U7_CHLSB 
Original site:  A0A0D9S6U7_CHLSB

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Ontology (8)   
   GO (8)   
Gene (4)   
   KEGG GENES (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (9)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (23)   

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ID   A0A0D9S6U7_CHLSB        Unreviewed;       942 AA.
AC   A0A0D9S6U7;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Calcium-activated chloride channel regulator 1 {ECO:0000256|ARBA:ARBA00041120};
GN   Name=CLCA1 {ECO:0000313|Ensembl:ENSCSAP00000016586.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016586.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000016586.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000016586.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the CLCR family.
CC       {ECO:0000256|ARBA:ARBA00006398}.
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DR   EMBL; AQIB01085675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007976268.1; XM_007978077.1.
DR   AlphaFoldDB; A0A0D9S6U7; -.
DR   STRING; 60711.ENSCSAP00000016586; -.
DR   Ensembl; ENSCSAT00000017099.1; ENSCSAP00000016586.1; ENSCSAG00000001434.1.
DR   KEGG; csab:103224507; -.
DR   eggNOG; ENOG502QRRD; Eukaryota.
DR   GeneTree; ENSGT00940000154682; -.
DR   OMA; QERVFVH; -.
DR   OrthoDB; 5479609at2759; -.
DR   BioGRID-ORCS; 103224507; 0 hits in 9 CRISPR screens.
DR   Proteomes; UP000029965; Chromosome 20.
DR   Bgee; ENSCSAG00000001434; Expressed in pituitary gland.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR004727; CLCA_chordata.
DR   InterPro; IPR013642; CLCA_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; NF041940; choice_anch_X; 1.
DR   NCBIfam; TIGR00868; hCaCC; 1.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF52; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1; 1.
DR   Pfam; PF08434; CLCA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00023049};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          335..504
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   942 AA;  103765 MW;  BDE3C81B723A8E6B CRC64;
     MCVFIYNGKE RHLHNPHFPK RETTGRCTAM GPFRSSVFIL ILHLLEGALS NSLIQLNNNG
     YEGIVIAIDP NVPEDETLIQ QIKDMVTQAS PYLFEATGKR FYFKNVAILI PETWKTKADY
     VRPKLETYKN ADVLVAESTP PDGDEPYTEH IGKCGDKGER IHLTPNFLAG KKLKEYGPQG
     RAFVHEWAHL RWGVFDEYNN DEKFYLSNGR IQAVRCSVGI TGKTEVNKCQ GGSCYTKRCT
     FNKATGLYEK GCEFIPHSQQ TEKASIMFAQ HVDSVVEFCT EQNHNKEAPN MQNTKCNLRS
     TWEVIRDSED FKKTTPTTTQ PPNPTFSLLQ IGQRIVCLVL DKSGSMATGN RLNRLNQAGQ
     LFLLQIIELR SWVGMVTFDS AAHVQSELIQ INSGSDRDTL TKRLPTAASG GTSICSGLRS
     AFTVIKKKYP TDGSEIVLLT DGEDNTISGC FNEVKQSGAI IHTVALGPSA ARELEELSTM
     TGGLRTYASD QVQNNGLIDA FGALSSGNGV VSQRSIQLES KGSTLQNSQW MNGTVIVDST
     VGKDTLFLVT WTTQPPQILL WDPSGQKQDG FVVDKNTKMA FLQIPGIAKV GTWKYSLQAS
     SQTLTLTVTS RASSATLPPI TVTSKMNKDT GKFPSPMIVY ANIRQGASPI LRASVTALIE
     SENGKTVTLE LLDNGAGADA AKDDGVYSRY FTTYDTNGRY SVKVRALGGV NAVRQRAIPQ
     QSGVMYIPGW IENDEIQWNP PRPEIEDDVQ RKQVCFSRTS SGGSFVASGV PNAPIPDLFP
     PCQITDLKAE IHGHSLINLT WTAPGDDYDH GTAHKYIIRI STSILDLRDK FNESLQVNTT
     ALIPKEANSE EVFLFKPENI TFENGTDLFI AIQAVDKADL KSEISNIARV SLFIPPQTPP
     ETPSPDETSA PCPNISINST IPGIHILKIM WKWIGELQLS IG
//

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