ID A0A0D9S8I0_CHLSB Unreviewed; 1019 AA.
AC A0A0D9S8I0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Pleckstrin homology and RUN domain containing M2 {ECO:0000313|Ensembl:ENSCSAP00000017169.1};
GN Name=PLEKHM2 {ECO:0000313|Ensembl:ENSCSAP00000017169.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000017169.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000017169.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000017169.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01141705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01141706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01141707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9S8I0; -.
DR STRING; 60711.ENSCSAP00000017169; -.
DR Ensembl; ENSCSAT00000017696.1; ENSCSAP00000017169.1; ENSCSAG00000000837.1.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00390000015175; -.
DR OMA; PSEMIHS; -.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000000837; Expressed in prefrontal cortex and 7 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR CDD; cd13309; PH_SKIP; 1.
DR CDD; cd17680; RUN_PLEKHM2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047327; RUN_PLEKHM2.
DR PANTHER; PTHR46556; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR PANTHER; PTHR46556:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 36..158
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 771..873
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 230..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 112965 MW; 311B2CA6EBFE6AE4 CRC64;
MEPREVKDRI LENISLSVKK LQSYFAACED ETPAIRNHDK VLQRLCEHLD HALLYGLQDL
SSGYWVLVVH FTRREAIKQI EVLQHVATNL GRSRAWLYLA LNENSFESYL RLFQENLGLL
HKYYGKNALV CSHDHLTLFL TLVSGLEFIR FELDLDAPYL DLAPYMPDYY KPQYLLDFED
RLPSSVHGSD SLSLNSFNSV TSTNLEWDDS AIAPSSEDYD FGDVFPAVPS VPSTDWEDGD
LTDTVSGPRS TASDLTSSKA STRSPTQRQN PFNEEPAETV SSSDTTPVHT TSQEKEEAQA
LDLPDTCTEL EVIRVTKKKK IGKKKKSRSD EEASPLHPAC SQKKCAKQGD SDSRNGSPSL
GRDSPDTTLA SPQEEGEGPS STTESSERSE PGLLIPEMKD TSMERLGQPL SKVIDQLNGQ
LDPSTWCSRA EPPDQSFRTG SPGDAPERPP LCDFSEGLSA PMDFYRFTVE SPSTVTSGGG
HHDPAGLGQP LHVPSSPEAA GQEEEGGGGE GQTPRPLEDT TREAQELEAQ LSLVRQGPVS
EPEPGTQEVL CQLKRDQPSP YLSSAEDSGV DEGQGSPSEM VHSSEFRVDN NHLLLLMIHV
FRENEEQLFK MIRMSTGHME GNLQLLYVLL TDCYVYLLRK GATEKPYLVE EAVSYNELDY
VSVGLDQQTV KLVCTNRRKQ FLLDTADVAL AEFFLASLKS AMIKGCREPP YPSILTDATM
EKLALAKFVA QESKCEASAV TVRFYGLVHW EDPTDESLGP APCHCSPPEG TITKEGMLHY
KAGTSYLGKE HWKMCFVVLS NGILYQYPDR TDVIPLLSVN MGGEQCGGCR RANTTDRPHA
FQVILSDRPC LELSAESEAE MAEWMQHLCQ AVSKGVIPQG VAPSPCIPCC LVLTDDRLFT
CHEDCQTSFF RSLGTAKLGD ISAVSTEPGK EYCVLEFSQD SQQLLPPWVI YLSCTSELDR
LLSALNSGWK TIYQVDLPHT AIQEASNKKK FEDALSLIHS AWQRSDSLCR GRASRDPWC
//
