ID A0A0E0KSN6_ORYPU Unreviewed; 1518 AA.
AC A0A0E0KSN6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Dicer-like protein 4 {ECO:0008006|Google:ProtNLM};
OS Oryza punctata (Red rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4537 {ECO:0000313|EnsemblPlants:OPUNC04G16040.5};
RN [1] {ECO:0000313|EnsemblPlants:OPUNC04G16040.5}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OPUNC04G16040.5}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: May interact with ARGONAUTE1 or PINHEAD through their common
CC PAZ domains. {ECO:0000256|ARBA:ARBA00011499}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|ARBA:ARBA00035116}.
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DR EnsemblPlants; OPUNC04G16040.5; OPUNC04G16040.5; OPUNC04G16040.
DR Gramene; OPUNC04G16040.5; OPUNC04G16040.5; OPUNC04G16040.
DR Proteomes; UP000026962; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF15; DICER-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF101690; PAZ domain; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000026962};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 329..488
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 506..596
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 808..872
FT /note="PAZ"
FT /evidence="ECO:0000259|PROSITE:PS50821"
FT DOMAIN 889..1067
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1108..1252
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1518 AA; 170508 MW; 04970388C411E44B CRC64;
MGDAAAASAA ATATAAGPSR TRGETKDPRT IARKYQLDLC KRAVEENIIV YLGTGCGKTH
IAVLLIYELG HLIRKPSREV CVFLAPTIPL VRQQAMVIAS STDFKVQCYY GNGKNSRVHQ
EWENDMREFE EFYNSNSVER FPRVFGMTAS PIIGKGGSNK LNYTKCINSL EELLHAKVCS
VDNEELESVV ASPDMEVYLY GPVNHSNLTV TYIKELDSLK LQSERILRES LCDFKDSQKK
LKSLWRLHEN IIFCLQELGS FGALQAAKTF LSFDGDKLDT KEVNLNGNTS SFAHYYLNGA
TSILSNNRTD GSHAGSFDLE TLEEPFFSDK FSVLINVLSR YGLQENMKCI VFVKRITVAR
AISNILRNLK CLDFWKCEFL VGCHSGSKNM SRNKMDAIVN LLVATSVGEE GLDIQTCCLV
VRFDLPETVA SFIQSRGRAR MTKSKYAVLL ERGNQSHEKL LKGYIAGESI MNEEIDSRTS
NDMFDCLEEN IYRVDNTGAS ISTACSVSLL HRYCDNLPRD MFFTPSPAFF YTDGIEGIIC
RLILPPNAAF RQVDGQPCLS KDEAKRDACL KACVKLHKLG ALTDFLLPGS GSRKNKVSTT
NNSSNNKVED DSLREELHEM LIPAVLKPSR LKLDCLSYLH FYYVKFIPIP EDRRYQMFGL
FVINPLPVEA ETLQMILAHK FQEMCLKILL DRSEFISPHV ILGNDVRLEM NSTFYLLLPI
KQKCYGDRFM IDWPAVERCL SSPIFKAPID VSVHGSYSPN ESLRLLDGIF SKTDVVGSVV
FSPHNNIFFF VDGILDEINA RSECSGATYV EHFKGRFGIE LSHPEQPLLK AKQLFNLRNL
LHNRLPETTE SEGRELLEHF VELPPELCSL KVIGFSKDMG SSLSLLPSLM YRLENLLVAI
ELKDVMSSSF PEASQISASG ILEALTTEKC LERISLERFE VLGDAFLKYV VGRHKFITYE
GLDEGQLTRR RSDVVNNSNL CELSIRKKLQ VYIRDQQFEP IQFFAPGRPC KVVCNTDVEV
SLHQMDIHPD NRENCNLRCT RSHHWLHKKV IADVVESLIG AFLVEGGFKA AFAFLHWIGI
DVDFNSSALY RVLDASSINL SLMGYTDIAG LEELIGYKFK HKGLLLQAFV HPSFSQHSGG
CYQRLEFLGD AVLEYVITSY LYSTYPDIKP GQITDLRSLA VGNDSLAYAA VEKSIHKHLI
KDSNHLTSAI SKFEIYVKLS NSEKDLLEEP ACPKALGDIV ESCIGAVLLD SGFNLNYVWK
VMLMLLKPVL TFSNMHTNPM RELRELCQCH GFELGLPKPM KADGEYHVKV EVNIKSKIII
CTAANRNSKA ARKFAAQETL SKLKNYGYKH RNKSLEEILN VARKRESELI GYNEDPIDVE
ADISVKMKSH EEKDADIPFQ NTETSFTGSS KFHNQIIAGD IKSGNHDVNN GRNNQPKLAT
QSGCLPSETT EKSNKKMYHG RAKPPSEVVV EMKGTSATLL ECHSDAKLQK KAAQEHAAQG
ALWCLKQLGH LPKEDVRA
//
